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EEG Statistical Analysis of Coherence Patterns in Depression and Machine Classification

우울증의 일관성 패턴에 대한 뇌파 통계 분석 및 기계 학습 분류

  • Ngumimi Karen Iyortsuun (Department of Artificial Intelligence Convergence, Chonnam National University, South Korea University) ;
  • Soo-Hyung Kim (Department of Artificial Intelligence Convergence, Chonnam National University, South Korea University) ;
  • Soonja Yeom (School of Information and Communication Technology, University of Tasmania) ;
  • Hyung-Jeong Yang (Department of Artificial Intelligence Convergence, Chonnam National University, South Korea University) ;
  • Aera Kim (Department of Artificial Intelligence Convergence, Chonnam National University, South Korea University)
  • ;
  • 김수형 (전남대학교 대학원 인공지능융합학과) ;
  • 염순자 (호주 태즈메이니아 대학교, 정보통신기술대학 ) ;
  • 양형정 (전남대학교 대학원 인공지능융합학과) ;
  • 김애라 (전남대학교 대학원 인공지능융합학과)
  • Published : 2025.05.29

Abstract

Depression's neurophysiological basis remains poorly understood, particularly regarding functional connectivity patterns. This study examines EEG coherence differences between 46 major depressive disorder (MDD) patients and 75 healthy controls (HC) from the PRED+CT dataset. Statistical analysis revealed significant reductions in global coherence across all frequency bands in depression, with the strongest effects observed in theta and delta bands. Support Vector Machine classification achieved promising performance, with the best results in the beta band (accuracy=83.28) despite this band showing the smallest statistical effects. This discrepancy suggests that different aspects of coherence data may contribute to biomarker development versus neurophysiological understanding of depression.

Keywords

Acknowledgement

This work was supported by the Institute of Information & Communications Technology Planning & Evaluation (IITP) under the Artificial Intelligence Convergence Innovation Human Resources Development (IITP-2023-RS-2023-00256629) grant funded by the Korea government (MSIT), the ITRC (Information Technology Research Center) support program (IITP-2024-RS-2024-00437718) supervised by IITP, the National Research Foundation of Korea(NRF) grant funded by the Korea government(MSIT) (RS-2023-00219107).

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