Hexachlorophene 유도체(遺導體)의 간(肝)디스토마증(症) 치료작용(治療作用)에 관(關)한 연구(硏究) (제 2 보)(第 2 報)

The Therapeutic Effects of Hexachlorophene Derivatives on Clonorchis sinensis in the Rabbits (Part 2)

The experimental rabbits were infested with 300 of metacercariae of Clonorchis sinensis. The therapeutic effects of following 6 kinds of hexachlorophene derivatives on infected rabbits were compared with those of hexachlorophene and 2,2-methylenebis (3,4,6-trichlorophenoxy acetic acid) (MTPA). The drugs were medicated by mouth for 7 days after infection of 40 days, and the following results were obtained. 1) The therapeutic effects of following four hexachlorophene derivatives are less potant than those of hexachlorophene and MTPA. 2) Among hexachlorophene derivatives, 2,2-methylenebis (3,4,6-trichlorophenoxy benzoylate) and 2,2-methylenebis (3,4,6-trichlorophenoxy ${\beta}-ethly$ alcohol) are more effective than 1,1-dihydroxy ethyl ether, 2,2-methylenebis (3,4,6-trichlorobenzene) (Table 1).