The Korean Journal of Pharmacology (대한약리학회지)

The Korean Society of Pharmacology (대한약리학회)
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Influence of Guanidine on the Effect of Acetylcholine

Acetylcholine의 작용(作用)에 미치는 Guanidine의 영향(影響)

  • Choi, Bek-Hi (Department of pharmacology, College of Medicine Woo Sok University) ;
  • Mok, Yeung-Za (Department of pharmacology, College of Medicine Woo Sok University) ;
  • Choi, Re-Yeun (Department of pharmacology, College of Medicine Woo Sok University)
  • 최백희 (우석대학교 의과대학 약리학교실) ;
  • 목영자 (우석대학교 의과대학 약리학교실) ;
  • 조래연 (우석대학교 의과대학 약리학교실)
  • Published : 1967.12.30
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Abstract

A few reports suggested that guanidine increases the quantity of acetylcholine released from the nerve endings and increases the sensitivity of the end plate to acetylcholine. In this experiment the authors attempted to investigate the influence of guanidine on the acetylcholine effect on the blood pressure of rabbits and excised intestine. The results obtained we re summarized as follows. 1. The hypotensive effect of acetylcholine on the rabbit is augmented by pretreatment with guanidine 5-10 mg/kg. however is inhibited by 20 mg/kg of guanidine. 2. The contractile effect of acetylcholine on the excised intestine of rabbit and rat is potentiated by guanidine.

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