대한약리학회지 (The Korean Journal of Pharmacology)

대한약리학회 (The Korean Society of Pharmacology)
권호 표지

인삼(人蔘) 각(各) Fraction이 Nembutal, Chlorpromazine 및 Reserpine 투여(投與)로 인(因)한 Mouse체온하강(體溫下降)에 미치는 영향(影響)

Influence of Each Fraction from Panax Ginseng on the Hypothermia in Mice Elicited by Reserpine, Nembutal and Chlorpromazine

  • 홍사악 (서울대학교 의과대학 약리학교실) ;
  • 조항영 (서울대학교 의과대학 약리학교실) ;
  • 홍순근 (중앙전매기술연구소)
  • Hong, Sa-Ack (Department of Pharmacology, College of Medicine, Seoul National University) ;
  • Cho, Hang-Young (Department of Pharmacology, College of Medicine, Seoul National University) ;
  • Hong, Soon-Keun (Section of Ginseng, Central Research Institute, Office of Monopoly)
  • 발행 : 1969.12.30
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초록

Saponin, essential oil, fat oil and alkaloidal fraction were fractionated from the ethanol extract of fanax ginseng. Effect of each fraction of Panax ginseng upon the temperature response induced by reserpine, chlorpromazine and nembutal was investigated in mice, so as to secure some hidden facets of each fraction of Panax ginseng acting upon central nervous system. The authors could arrive at some results, that is: (1) Inhibitory effect of Panax ginseng upon temperature decline induced by nembutal and chlorpromazine and potentiating action upon hyperthermia induced by reserpine reside mainly in saponin fraction and slightly in essential oil fraction. (2) The effect of Ginseng saponin on temperature response in nice seems to be related with the liberation of serotonin and histamine.

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