Bradykinin 이 Guanethidine 전처치(前處置) 가토(家兎)의 혈압(血壓)에 미치는 영향(影響)

Influence of Bradykinin on Blood Pressure in the Rabbit pretreated with Guanethidine

It is well known that pharmacological actions of bradykinin are smooth muscle dilatation, increase in capillary permeability, accumulation and migration of leucocytes and inducement of pain. The most significant action of bradykinin is the dilatation of blood vessels. The responses of bradykinin (0.5ug/kg, i. v. injection) on blood pressure were observed before and after single i. v. administration of guanethidine (2mg/kg) in the rabbits. The result of experiment was as follows: In the rabbit pretreated with guanethidine, the depressor response of bradykinin was much pronounced in comparison with that of normal rabbit.