The Korean Journal of Pharmacology (대한약리학회지)

The Korean Society of Pharmacology (대한약리학회)
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The Influence of Sodium Fluoride on the Release of Catecholamine from Perfused Organs and Monoamine Oxidase Activity

Fluoride가 적출장기(摘出臟器)의 Catecholamine 유리(遊離) 및 Monoamine Oxidase 활성도(活性度)에 미치는 영향(影響)

  • Cheon, Yun-Sook (Department of Pharmacology, College of Medicine, Korea University) ;
  • Kim, Sung-Sook (Department of Pharmacology, College of Medicine, Korea University) ;
  • Lee, Kyung-Hee (Department of Pharmacology, College of Medicine, Korea University) ;
  • Shin, Kyung-Chul (Department of Pharmacology, College of Medicine, Korea University)
  • 천연숙 (고려대학교 의과대학 약리학교실) ;
  • 김성숙 (고려대학교 의과대학 약리학교실) ;
  • 이경희 (고려대학교 의과대학 약리학교실) ;
  • 신경철 (고려대학교 의과대학 약리학교실)
  • Published : 1972.12.30
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Abstract

Fluorides were supposed to exert a stimulatory action on the catecholamine release. In this study, the authors attempted to investigate the action of sodium fluoride on the catecholamine release from the isolated perfused cow adrenal gland and rat heart. And also the inhibitory effect of sodium fluoride on the monoamine oxidase activity in rat heart and liver mitochondria was investigated. The monoamine oxidase activity was measured by the conversion of benzylamine to benzaldehyde. The results obtained were follows; 1. Sodium fluoride stimulated the release of catecholamine from the isolated perfused cow adrenal gland and rat heart. 2. Sodium fluoride inhibited the rat heart and liver mitochondrial monoamine oxidase activity.

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