대한약리학회지 (The Korean Journal of Pharmacology)

대한약리학회 (The Korean Society of Pharmacology)
권호 표지

오수유(吳茱萸) Evodiae Fructus 방향성물질(芳香性物質)의 약리학적(藥理學的) 연구(硏究)

Pharmacologic-Action of Essential Substance Obtained from Fruits of Evodia rutaecarpa

  • 노영근 (경희대학교 의과대학 약리학교실) ;
  • 정지창 (경희대학교 의과대학 약리학교실) ;
  • 고계창 (경희대학교 의과대학 약리학교실) ;
  • 韓大燮 (경희대학교 의과대학 약리학교실)
  • Rho, Young-Geun (Department of Pharmacology, School of Medicine, Kyung Hee University) ;
  • Jung, Jee-Chang (Department of Pharmacology, School of Medicine, Kyung Hee University) ;
  • Ko, Kye-Chang (Department of Pharmacology, School of Medicine, Kyung Hee University) ;
  • Han, Dae-Sup (Department of Pharmacology, School of Medicine, Kyung Hee University)
  • 발행 : 1980.06.01
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초록

The Pharmacologic action of ethanol extracts and essential substance obtained from fruits of Evodia rutaecarpa are studied. 1) Motility of the isolated rabbit-intestine was decreased in proportion to the concentration of essential substance. 2) Intestinal contraction induced by acetylcholine 10? 6g/ml was inhibited by the essential substance $10^{-5}g/ml$. 3) Contractile responses of the isolated rabbit-intestine by serotonin $10^{-5}g/ml$ and histamine $10^{-5}g/ml$ were depressed significantly with the essential substance $10^{-5}g/ml$. 4) Alpha adrenergic receptor blocking effect of dihydroergotamine was interfered significantly with the essential substance. 5) Analgesic effect in mice by acetic acid stimulating method was observed significantly with both of the ethanol extracts and essential substance. 6) Blood pressure and respiration of the rabbits were not significantly influenced with the essential substance.

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