The Korean Journal of Pharmacology (대한약리학회지)
- Volume 19 Issue 1
- /
- Pages.77-84
- /
- 1983
- /
- 0377-9459(pISSN)
Effects of Adenosine and CNS Stimulants on Motor Activity in Mice
중추신경흥분제 및 Adenosine이 마우스의 자발운동에 미치는 영향
- Kwaak, Jung-Jae (Department of Pharmacology, Yonsei University College of Medicine) ;
- Kim, Hea-Young (Department of Pharmacology, Yonsei University College of Medicine) ;
- Kim, Won-Joon (Department of Pharmacology, Yonsei University College of Medicine)
- Published : 1983.06.30
Abstract
The behavioral pattern of an animal is influenced by endogenous and endogenous stimuli such as humoral secretion, neurohumoral transmitters, drugs, light and environmental change. It has teen known that adenosine is a normal constituent of brain, and has sedative or hypnotic effects and anticonvulsant effects, inhibiting the spontaneous firing of cells in the brain via membrane adenosine receptors. Recent studies suggest that the excitatory responses to xanthines in the CNS might be related to the competitive antagonism of xanthines to adenosine. This study was undertaken to Investigate the effects of adenosine and the CNS stimulants such as picrotoxin, strychnine and caffeine on the spontaneous activity of mire, and to examine the influence of adenosine on the seizures induced by large doses of CNS stimulants. Subjects were
Keywords