Toxicological Research
- 제4권2호
- /
- Pages.85-94
- /
- 1988
- /
- 1976-8257(pISSN)
- /
- 2234-2753(eISSN)
EFFECTS OF AQUEOUS EXTRACT OF A POISONOUS MUSHROOM, AMANITA PANTHERINA ON MICE AND ASSAY OF TOXIC ISOXAZOLE DERIVATIVES BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
- Yoshio Yamaura (Nagono Research Institute for Public Health) ;
- Chang, Il-Moo (Natural Products Research Institute, Seoul National University)
- 발행 : 1988.12.01
초록
In order to elucidate the mechanism of toxic action of a pisonous mushroom, Amanita pantherina, biochemical effects of the mushroom extracts on mice were studied. A hotwater extract of Amanita pantherina injected intraperitoneally into male ICR mice evoked signs similar to those observed clinically upon acute poisoning by the mushroom and also changed the levels of component enzyme activities in blood, liver and urine. The serum cholinesterase activity was decreased significantly during 1-3 h after injection.
키워드