The Korean Journal of Physiology
- Volume 24 Issue 1
- /
- Pages.1-13
- /
- 1990
- /
- 0300-4015(pISSN)
Effects of Electrolytes and Drugs on the Inhibitory Junction Potentials Recorded from the Antrum of Guinea-pig Stomach
기니피그 유문동에서 기록되는 억제성 접합부 전압에 미치는 전해질과 약물의 효과
- Goo, Yong-Sook (Department of Physiology,College of Medicine,Chungbuk National University) ;
- Suh, Suk-Hyo (Department of Physiology,College of Medicine,Dongkuk University) ;
- Lee, Suk-Ho (Department of Physiology,College of Medicine,Seoul National University) ;
- Hwang, Sang-Ik (Department of Physiology,College of Medicine,Seoul National University) ;
- Kim, Ki-Whan (Department of Physiology,College of Medicine,Seoul National University)
- 구용숙 (충북대학교 의과대학 생리학교실) ;
- 서석효 (동국대학교 의과대학 생리학교실) ;
- 이석호 (서울대학교 의과대학 생리학교실) ;
- 황상익 (서울대학교 의과대학 생리학교실) ;
- 김기환 (서울대학교 의과대학 생리학교실)
- Published : 1990.06.30
Abstract
The effects of electrolytes, adenosine, ATP, 5-hydroxytryptamine (5-HT, serotonin) and ketanserin on the inhibitory junction potentials (IJPs) were investigated to clarify the interactions of these drugs with the neurotransmitters released from non-adrenergic, non-cholinergic nerves in the antrum of guinea-pig stomach. Electrical responses of antral circular muscle cells were recorded intracellularly using glass capillary microelectrode filled with 3 M KCI. All experiments were performed in Tris-buffered Tyrode soluition which was aerated with 100%
기니피그 유문동 부위를 절제한 뒤 점막층을 박리하고 윤상근 주행방향으로 길이 10 mm, 너비 2 mm 되는 조직 절편을 만들어 수평형 실험용기에 넣어 핀으로 고정하였다. 유리미세전극을 세포내에 삽입하여 서파를 기록하면서 조직양편에 설치한 백금자극전극(직경 0.5 mm)에 강도
Keywords
- Inhibitory junction potential (IJP);
- Excitatory junction potential (EJP);
- Non-adrenergic non-cholinergic nerves;
- $Ca^{2+}$ dependent $K^{+}$ channel