Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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몇가지 중금속이 배양 섬유모세포에 미치는 세포독성에 관한 연구

  • 정연태 (원광대학교 의과대하교 해부학) ;
  • 박승택 (원광대학교 의과대하교 해부학) ;
  • 김정중 (원광대학교 의과대하교 해부학) ;
  • 최봉규 (원광대학교 약리학교실) ;
  • 우원홍 (원광대학교 한의과대학) ;
  • 위인선 (전남대학교 생물학과)
  • Published : 1992.06.01
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Abstract

Present study was carried out to investigate the cytotoxicity of cadmium, chromium and mercury on cultured rat fibroblasts. The colorimetric assays of neutral red (NR) and tetrazolium MTT, the measurement of total content of protein and electron microscopic studies were performed on the fibroblasts cultured in the media containing various concentrations of cadmium, chromium and mercury. The results are as follows' 1. In cadmium-treated group, the NR and MTT values were dose-dependent increase. The NR90, NR50, MTT90 and MTT50 values of cadmium were 0.2mM, 19.5mM 1.0mM and 60.0mM, respectively.

Keywords

References

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