Applied Chemistry for Engineering (공업화학)

The Korean Society of Industrial and Engineering Chemistry (한국공업화학회)
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Permeation Properties of Insulin through Chitosan-g-Poly(4-vinyl pyridine ) Membrane

Chitosan-g-Poly(4-vinyl pyridine) 공중합체막을 통한 인슐린의 투과 특성

  • Kim, Kong Soo (Dept. of Industrial and Eng. Chem., Chungbuk Nat'l Univ.) ;
  • Kang, Seog Ho (Dept. of Industrial and Eng. Chem., Chungbuk Nat'l Univ.) ;
  • Kim, Soo Jong (Dept. of Industrial and Eng. Chem., Chungbuk Nat'l Univ.) ;
  • Lim, Jeong Kyu (Lucky Ltd. Household Goods Res. Inst.)
  • 김공수 (충북대학교 공과대학 공업화학과) ;
  • 강석호 (충북대학교 공과대학 공업화학과) ;
  • 김수종 (충북대학교 공과대학 공업화학과) ;
  • 임정규 ((주)럭키 생활용품연구소)
  • Received : 1994.01.17
  • Accepted : 1994.05.17
  • Published : 1994.08.01
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Abstract

Chitosan-g-poly(4-vinyl pyridine)membranes were prepared by crosslinking reaction using glutaraldehyde and glucose oxidase immobilized chitosan/acrylamide composite membranes were fabricated by chitosan-g-poly(4-vinyl-pyridine) copolymer and acrylamine. Water content and permeability of insulin through chitosan-g-poly(4-vinyl pyridine )membranes increased with decreasing the pH of the medium. Permeability of insulin through chitosan/acrylamide composite membranes increased with increasing the concentration of glucose.

Chitosan-g-Poly(4-vinyl pyridine)공중합체막을 제조하였으며 Chitosan-g-Poly(4-vinyl pyridine)공중합체막과 아크릴아마이드를 사용하여 glucose oxidase를 포함하는 chitosan/acrylamide 복합막을 제조하였다. Chitosan-g-poly(4-vinyl pyridine)공중합체막의 함수율과 인슐린의 투과량은 용액의 pH가 감소함에 따라 증가하였고, 복합막의 인슐린 투과량은 글루코오스의 농도가 증가할수록 증가하였다.

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