The Korean Journal of Pharmacology (대한약리학회지)
- Volume 31 Issue 2
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- Pages.251-259
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- 1995
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- 0377-9459(pISSN)
Pharmacokinetic/Pharmacodynamic Analysis of Metoprolol in Dogs
실험견에서 Metoprolol 약리효과의 약동/력학적 검토
- Oh, Dong-Jin (Department of Internal Medicine Hallym University College of Medicine) ;
- Jang, In-Jin (Dept of Pharmacology Seoul National University College of Medicine,Clinical Pharmacology Unit SNUH) ;
- Lee, Kyung-Hun (Dept of Pharmacology Seoul National University College of Medicine,Clinical Pharmacology Unit SNUH) ;
- Yim, Dong-Seok (Dept of Pharmacology Seoul National University College of Medicine,Clinical Pharmacology Unit SNUH) ;
- Kim, Hyung-Kee (Dept of Pharmacology Soonchunhyang University College of Medicine) ;
- Shin, Sang-Goo (Dept of Pharmacology Seoul National University College of Medicine,Clinical Pharmacology Unit SNUH) ;
- Park, Chan-Woong (Dept of Pharmacology Seoul National University College of Medicine) ;
- Shin, Jae-Gook (Dept of Pharmacology Inje University College of Medicine)
- 오동진 (한림대학교 의과대학 내과학교실) ;
- 장인진 (서울대학교 의과대학 약리학교실,서울대학교병원 임상약리실) ;
- 이경훈 (서울대학교 의과대학 약리학교실,서울대학교병원 임상약리실) ;
- 임동석 (서울대학교 의과대학 약리학교실,서울대학교병원 임상약리실) ;
- 김형기 (순천향대학교 의과대학 약리학교실) ;
- 신상구 (서울대학교 의과대학 약리학교실,서울대학교병원 임상약리실) ;
- 박찬웅 (서울대학교 의과대학 약리학교실) ;
- 신재국 (인제대학교 의과대학 약리학교실)
- Published : 1995.09.30
Abstract
Pharmacokinetics and pharmacodynamics of metoprolol, a selective beta-l blocker, were examined for 360 minutes after intravenous bolus administration of metoprolol to 6 dogs. Plasma concentration and excreted amount in the urine metoprolol were measured by liquid chromatography with fluorescence detection. PR interval and heart rate were measured by ECG monitoring. Blood pressure was monitored through intraarterial catheter in femoral artery and cardiac output by thermodilution method using Swan-Ganz catheter. To analyze the effect site concentration-response relationship, plasma concentration and pharmacological effects were simultaneously fitted to a two pharmacokinetic compartment linked to pharmacodynamic model with NONLIN program. Results are as follows. 1) The plasma concentration of metoprolol after intrvenous injection decreased biexponentially. The terminal half-life estimated was