아스코르빈산-리듐 유도체의 바이러스에 대한 불활성화 작용

Antiviral Effect of Lithium-Ascorbate Derivatives

  • Kil-Jin Kang (Dept. of Food Science and Technology, and Institute of Agriculture Science & Technology, Chonnam National University) ;
  • Akira Murata (Dept. of Applied Biological Science, Saga University)
  • 발행 : 1995.06.01

초록

아스코르빈산-리듐 유도체의 항바이러스의 작용을 검토하기 위하여 여러 종의 박테리아 파이지를 이용하여 이에 대한 불활성화를 조사하였다.아르코르빈산-리듐 유도체는 조사된 모든 파야지에 대하여 불활성화를 보이므로서 항바이러스 작용이 있음을 알 수 있었다. Lithium 2-o-octadecyl ascorbate의 파야지 불활성화 작용은 lithium ascorbate와 아스코르빈산 보다 10~20배 정도 강하였다. 이러한 결과들은 아스코르빈산-리듐 유도체도 아스코르빈산과 마찬가지로 항바이러스 작용이 있으며 그 정도는 아르코르빈산과 비슷하거나 또는 좀 더 강함을 보여 주었다.

The effect of lithium-ascorbate derivatives on viruses was investigated using a wide variety of bacterial viruses(phage). Lithium-ascorbate derivatives exerted an inactivating effect on all phages examined. Lithium-ascorbate derivatives have antiviral effects. The antiviral effect of lithium 2-o-octadecyl ascorbate was stronger than that of lithium ascorbate. Even at 10∼20 times lower concentration, the lithium 2-o-octadecyl ascorbate showed very much similar phage inactivating effect to that of ascorbate and lithium ascorbate.

키워드

참고문헌

  1. Congr. Int. Assoc. Microbioal. Soc. v.3 Virucidal activity of vitamin C, in Proc. 1st. Intersect. Murata,A.;Hasegawa,T.(ed.)
  2. Virus-inactivating effect of L-ascorbic acid v.20 Tanpkkushitsh Kakusan Koso(Protein Nucleic acid Enzyme.) Murata,A.
  3. J. Nutr. Sci. Vitaminol. v.21 Mechanisom of inactivation of phage δ A by ascorbic acid. Murata,A.;Oyadomari,R.;Ohashi,T.;Kitagawa,K.
  4. J. Nutr. Sci. Vitaminol. v.22 Mechanism of inactivation of pharge MS2 by asorbic acid. Murata,A.;Uike,M.
  5. Bitamin(vitamins) v.57 Inactivating effect of ascorbic acid on double-stranded RNA phage. Murata,A.;Suenaga,H.;Inoue,M.;Tanaka,Y.;ato,F
  6. Agric. Biol. Chem. v.37 Mechanism of in activation of pharge by ascorbic acid. Murata,A.;Kitagawa,K.
  7. Agic. Biol. Chem. v.50 Hydroxyl radical as the reactive species in the inactivation of phages by ascorbic acid. Murata,A.;Sunenga,H.;Hideshima,S.;Tanaka,Y.;Kato,F.
  8. Biosci. Biotech. Biochem. v.56 Phage-inactivating effect of iron(Ⅱ)-ascorbate complex. Lho,I.H.;Morita,K.;Myyake,H.;Sakamoto,K.;Kanda,K.;Kato,F.;Murata,A.
  9. Agric. Biol. Chem. v.35 Temperature-sensitive growth of wild-type phage Ⅱ of Lactoacillus casei. Murata,A.
  10. J. Virol. v.11 Phage Φ6 ;a lipid-containing virus of Pseudomonas phaseolicola. Vidaver,A.K.;Koshi,P.K.;Van Etten,J.L.
  11. Bacteriophages. Adams,M.H.
  12. Factors influencing plaque formation by phages of Lactobacillus acidophilus. v.43 Murata,A.;Soeda,E.;Saruno,R.