Journal of Photoscience

Korean Society of Photoscience (한국광과학회)
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CALCIUM EFFECTS OF VISUAL ADAPTATION IN A VERTEBRATE RETINA (I)

  • ung, Hyuk J (Department of Biochemistry, College of Natural Sciences, Kyungpook National University, Taegu, 702-701, Korea)
  • Published : 1996.09.01
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Abstract

Calcium has a variety of functions in neuron and muscle cells and blood clotting, especially in the visual system where dark adapted rods cotransport with Na$^+$ into the cell. An influx of Ca$^{2+}$ flows out of the cell through the Na$^+$ - Ca$^{2+}$ exchanger. By using a modified Ussing chamber in order to bring in vivo environment close, we have concluded that Ca$^{2+}$ blocks the activity of guanylate cyclase; in consequence, having an effect on the amplitude of electroretinogram (ERG). We suggest that Ca$^{2+}$ moves between the photoreceptor and the vitreous humor by way of certain Ca$^{2+}$ transport mechanisms. Also, the effect of Zn$^{2+}$ in Ca$^{2+}$ - free ringer solution caused an elevation of amplitude in ERG and a reduction of threshold.

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References

  1. 9th ed Medical Physiology. v.54 no.67 Arthur, C. G.;J. E. Hall.
  2. Proc. Natl. Acad Sci. USA v.85 Ion transport by the Na-Ca exchange in isolated rod outer segment. Lagnado, L.;L. Cervetto;P. A. McNaughton
  3. Science v.268 Calcium signaling in neuton: Molecular mechanisms and cellular consequence. Ghosb, A.;M. E. Greenberg
  4. Review of Medical Physiology. 6th ed. Ganong, W. F.
  5. Exp. Eye Res. v.55 Isochemia and reperfusion-induced $Na^{+}$,$K^{+}$.$Ca^{2+}$,and $Mg^{2+}$ shifts in rat retina : Effect of two free fadical scavinger, SOD and EGB 761. Szabo, M. E.;M. T. Droy-Kefaix;M. Doly;P. Braquet
  6. Nature v.242 Effect of Magnesiym on horizontal cell activity in the skate retina. Dowling, J. E.;H. Ripps
  7. Nature v.313 Light induced reduction of cytoplasmic free calcium in retinal rod ouer segment. Yau, K.-W.;K. Nakatani
  8. Proc. Natl. Acad. Sci. USA v.83 Plasma membrane calcium fluxes in intact rods are inconstant with the Calcium hypothesis. Gold, G. H.
  9. Nature v.334 Calcium and light adaption in retinal rods and cones. Yau, K.-W.;K. Nakatani
  10. Sodium-Calcium Exchange Oxford Allen, T. J. A.;D. Noble;H. Reuter
  11. Brain Research v.113 Light evoked release of glycine fron cat and rabbit retina. Ehinger, B.;B. Lindberg-Bauer
  12. J. Physiol. v.376 Synaptic transmession in amphibian retinae during conditions unfavourable for calcium entry into presynaptic terminals. Schwartz, E. A.
  13. Proc. Natl. Acad. Sci. USA v.82 Interaction of hydrolyses-resestant analoues of cyclic GMP with the phosphodiestease and light sensitive channel of retinal rod outer segment. Zimmerman, A.;G. Yamanaka;F. Eckstein;D. A. Baylor;L Stryer
  14. Nature v.334 High degree of cooperativity in the inhidition of retinal rod guanylate cydlase by calcium. Koch, D.-W.;L. Stryer
  15. Proc. Natl. Acad. Sci. USA v.84 Role of calcium in regulating the cyclic GMP cascade of phototransduction in retinal rod. Torre, V.;H. R. Matthews;T. K. Lamb
  16. J. Physiology v.391 The drrdct of inos on sodium-calcoum exchange in salamander rods. Hodgkin, A. L.;B. J. Nunn
  17. Science v.258 A function connection between the pores of distantly related ion channel as revealed by mutant $K^{+} channels. Higinbotham, L.;t. Abramaon;R. MacKinnon
  18. J. Physiol. v.358 The ionic selectivity and calcium dependence of the light sensitive pathway in toad rod. Hodgkin, A. L.;P. A. McNaughton;B. J. Nunn
  19. Cell v.80 Calcium signaling Clapham. D. E.