한국식품영양과학회지 (Journal of the Korean Society of Food Science and Nutrition)

  • 제25권6호
  • /
  • Pages.958-962
  • /
  • 1996
  • /
  • 1226-3311(pISSN)
  • /
  • 2288-5978(eISSN)
한국식품영양과학회 (The Korean Society of Food Science and Nutrition)
권호 표지

해조류 참도박의 메탄올 추출물이 고지방식이 흰쥐의 지질성분에 미치는 영향

Effect of Methanolic Extract of Pachymeniopsis elliptica on Lipids Component of Hyperlipidemic Rats

  • 박종철 (순천대학교 한약자원학과) ;
  • 장영인 (순천대학교 사회체육학과) ;
  • 도명술 (한동대학교 생물식품공학부) ;
  • 김석환 (동아대학교 식품영양학과) ;
  • 최종원 (경성대학교 약학대학)
  • 발행 : 1996.12.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

해조류인 참도박으로 부터 고지혈증 개선효과를 관찰하기 위하여 고지혈증을 유발시킨 흰쥐에 메탄올 추출물을 투여하고 혈액 및 간조직에서의 지방 함량을 측정하였다. 그 결과 참도박의 메탄올 추출물의 투여는 지방조직의 무게는 정상군에는 미치지 않으나 대조군에 비해 다소 감소하는 경향을 보였다. 고지방식이로 인위적으로 고지혈증을 유발시켰을때 정상군보다 total cholesterol, LDL-cholestero의 함량이 증가되던 것이 추출물의 투여로 total cholesterol의 함량이 현저히 감소되었으나 LDL-cholesterolt의 함량은 별다른 영향이 없었다. 또한 이들의 고지방식이군 보다 total lipid, triglyceride의 함량도 감소시켰다.

Hypolipidemic effect of methanolic extract of marine algae, Pachymeniopsis elliptica was examined in hyperlipidemic rats. Male $Sprague-Dawley(120\pm5g)$ rats were divided into five groups and fed high fat diets for four weeks. Each group was orally administered with methanolic extract of P. elliptica (PEM, 250, 500mg/kg), benzofibrate(BZF, 30mg/kg) and cholestyramine resin(CSR, 100mg/kg) daily for one week. Significant decreases in cholesterol, total lipid and triglyceride of both blood and liver were observed by the administration of the extract. But the levels of LDL- and HDL-cholesterol and the activity of lipase were not changed. Such results suggest that the extract may promote the fecal excretion of bile acid in hyperlipidemic rats.

키워드

참고문헌

  1. 수산과학의 하이테크 정지형;김영섭(편집);정현도(편집)
  2. 한국통계년감 경제기획원 조사통계국
  3. Clin. Chem. v.34 Drug therapy hypercholesterolemia Illongworth, D. R.
  4. Annu. Rev. Pharmacol. Toxicol. v.26 The pharmacological treatment of dyslipidemia Dejovine, C. A.;Harris, W. S.
  5. Stroke v.15 Italian multicenter study on reversible cerebral cerebrovascular atherosclerosis Candelise, L.;Bianchi, F.;Albanaese, V.;Bonelli, G.;Bossao, L.;Inzitari, D.;Mariani, F.;Rasura, M.;Rognoni, F.;Sangiovanni, G.;Fieschi, C.
  6. Stroke v.19 Relation between blood lipid, lipoproteins and cerebrovascular atheroscrelosis Teli, G.;Crouse, J. R.;Furberg, C. D.
  7. 생약학회지 v.27 수산생물자원 추출물의 과산화지질생성의 억제효과 박종철;최종원
  8. Arch. Pharm. Res. v.19 Antioxidant activity of Ecklonia stolonifera Lee, J. Y.;Par, J. C.;Choi, J. S.
  9. Clin. Chem. v.24 Stimultaneous determination of serum cholesterol in high- and low-density lipoproteins with use of heparin, $Ca^{++}$, and an anion exchange resin Noma, A.;Nakayama, K. N.;Kita, M.;Okabe, H.
  10. Clin. Chem. v.25 Improved method for simultaneous determination of cholesterol in high- and low-density lipoprotein Noma, A.;Okabe, H.;Nakayama, K. N.;Ueno, Y.;Shinohara, H.
  11. Clin. Chem. v.13 A specific method for serum lipase determination Tietz, N. W.;Fiereck, E. A.
  12. Little Med. v.19 New method of determination of the lipase activity of the serum, clinical application Fruchart, J. C.;Sezille, G.;Juillard, J.
  13. J. Biol. Chem. v.226 A simple method for the isolation and perification of total lipids from animal tissues Folch, J.;Lees, M.;Stanley, G. H.
  14. Hokkaido J. Med. Sci. v.38 The effect of cholesterol-feeding on the tissue lipids Ichida, T.
  15. Lipid v.13 The evidence for the antiatherogenicity of high density lipoprotein in man Miller, N. E.
  16. New Engl. J. Med. v.314 The pathogenesis of atherosclerosis Ross, R.
  17. Clin. Chem. v.17 A rapid and reliable measurement of serum lipase activity Yang, J. S.;Biggs, H. G.
  18. Int. J. Sports Med. v.9 Heparin-released plasma lipase activities, lipoprotein and apoprotein levels in young adult cyclists and sedentary men Giada, F.;Baldo-Enzi, G.;Balocehi, M. R.;Zaliani, G.;Baroni, L.;Fellin, R.
  19. Annu. Rev. Med. v.33 Therapy of hyperlipidemic states Havel, R. J.;Kane, J. P.
  20. Annu. Rev. Med. v.37 Treatment of hyperlipidemia Kane, J. P.;Havel, R. J.
  21. Adv. Intern. Med. v.39 Medical management of hyperlipidemic states Malloy, M. J.;Kane, J. P.
  22. Med. Clin. North Am. v.66 treatment of hyperlipidemia Kane, J. P.;Malloy, M. J.
  23. Biochem. J. v.289 Hepatic cholesterol synthesis and the secretion of newly synthesized cholesterol in bile Robins, S. J.;Fasulo, J. M.;Lessard, P. D.;Patton, G. M.