Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Inhibitory Effects of Tannic Acid on the Skin Toxicity and Heat Shock Protein Induction by UVB Irradiation in Hairless Mouse

자외선 B 파로 유도된 Hairless Mouse에서 타닌의 피부 독성 억제효과 및 Heat Shock Protein 70의 생성억제 효과

  • 이세윤 (동덕여자대학교 종합약학연구소) ;
  • 이민경 (동덕여자대학교 약학과) ;
  • 장동덕 (동덕여자대학교 식품의약품안전본부) ;
  • 안령미 (동덕여자대학교 보건관리학과) ;
  • 안형수 (동덕여자대학교 약학과)
  • Published : 1997.06.01
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Abstract

Inhibitory effects of tannic acid on skin toxicity and heat shock protein induced by UVB were investigated. Tannic acid was administered either topically or orally for 3 days to hairless mice, which were previously irradiated with UVB. UVB was found to cause skin erythema . However, the skin erythema was decreased when tannic acid was administered either topically or orally. The heat shock proteins, Hsp-78 kDa and 70 kDa, were induced by UVB irradiation, but the induction was decreased by treatment of tannic acid in both topically and orally administered groups. The hsp induction was more prominent in orally administered groups than in topically administerd groups. However, the difference between two groups was not statistically significant. The route of administrations, topical and oral, does not affect the activity of tannic acid. In the skin tissue observation, tannic acid regenerated the epithelial cells with 7-9 cell layers which were injured by UVB. In conclusion, tannic acid has an ability to protect against UVB irradiation and regenerate the skin.

Keywords

References

  1. J. Invest. Dermatol. v.73 no.3 Ultraviolet light depletes surface markers of langerhans cells Aberer, W;Schuler, G;Stingl, G;Herbert, H;Klaus, W
  2. Science v.259 Regulation of the human promoter by p53 Agoff, S.N.;Hou, J.;Linzer, D.I.H.;Wu. B.
  3. Dermatotoxico-logy(3rd edited) Light-induced dermal toxicity: effects on the cellular and molecular level Andrija, K.;Wayne. W.;Albert, G. Jr.;Francis, N. M.;Howard, I. M.
  4. Photochem. Photobial v.50 Wavelength dependence of histological, physical, and visible changes in chronically UV-irradiated hairless mouse skin Bissett, D.L.;Hannon, D.P.;Orr, T.V.
  5. J. Invest. Dermatol v.83 In vitro effect of UV radiation on immune function and membrane markers of human langerhans cells Czernielewski, J.;Vaigot, P.;Asselineau, D.(et al.)
  6. Photochem. Photobiol v.46 no.3 An animal model of solar aged skin : Histological, physical, and visible changes in UV irradiated hairless mouse skin Donald, L.B.;Daniel, P.H.;Thomas, V.O.
  7. Dermatotoxicology, Principles and Methods of toxicology(2nd edited) Esther, P.;Howard, I.M.;A.Wallace Hayes.
  8. Dermatology Trend in dermatology-Ozone depletion and dermatologist Need we prepare for the consequences of a UVB Holocaust in next decades Fitzpatrick, T.B.;Sober, A.J.;Fitzpatrick, T.B.
  9. Chung. Kuo. I. Hsueh. Yuan. Hs-ueh. Pao v.13 Protective effect of tannic acid against TPA and cigarette smoke condensate induced DNA strand breaks in human white cells and its antioxidant action Fu. N.
  10. Anticancer Res v.13 Antitumor-promoting effects of gallotannins extracted from various sources in mouse skin in vivo Gali, H.U.;Perchellet, E.M.;Gao, X.M.;Bottari, V.;Perchellet, J.P.
  11. Dermatology in General Medicine Acute effects of ultraviolet radiation in the skin Gange, R.W.;Fitzpatrick, T.B.;Eisen, A.Z.;Wolff, K.(3rd et al.)
  12. Nutr. Cancer v.22 Prevention of photocarcinogenesis and UV-induce immunosuppression in mice by topical tannic acid Gensler, H.L.;Gerrish, K.E.;Williams, T.;Rao, G.
  13. Cancer Lett. v.83 Inhibition of mammary gland carcinogenesis by green tea catechins and other naturally occurring antioxidants in female Sprague Dawley rats protected with 7,12-dimethylbenz(alpha)anthracene Hirose, M.;Hoshiya, T.;Akagi, K.;Futakuchi, M.;Ito, N.
  14. Mutagenesis v.9 Moderate inhibition of mutagenicity and carcinogenicity of benzo(a)pyrene, 1,6-d-initropyrene and 3,9-dinitrofluoranthene by Chinese medicinal herbs Horikawa, K.;Mohri, T.;Tanaka, Y.;Yokiwa, H.
  15. Photodermatol. v.2 Effect of ultraviolet radiation on guinea pig epidermal Langerhans cell cytomembrane. Light and electron microscopic studies Iacobelli, D.;Hashimoto, K.;Takahashi, S.
  16. J. Invest. Dermatol. v.78 New melanogenesis and photobiological processes in activation and proliferation of precursor melanocytes after UV exposure : Ultrastructural differentiation of precusor melanocytes from langerhans cell Jimbow, K.;Uesugi, T.
  17. Cancer res v.49 Correlation between the induction of heat shock protein 70 and enhanced viral reactivation in mamalian cells treated with Ultraviolet light and heat shock Kandace, J.W.;Bryan, E.L.;Narda, L.W.;Joanne Z.
  18. Biochem. Biophys. res. com. v.186 Augmented expression of HSP72 protein in normal human fibroblasts irradiated with ultraviolet light Keiji, S.;Masami, W.
  19. J. Am. Acaid. Dermatol. v.3 Sunscreens prevent ultraviolet photocarcino genesis Kligman, L.H.;Akin, F.I.;Kligman, A.M.
  20. Nature v.277 Cleavage of structural proteins during the assembly of the head of bacteriophage T₄ Laemmli, U.K.
  21. J. Invest. Dermatol. v.95 Ultraviolet radiation can either suppress or induce expression of intercellular adhesion molecule I (ICAM-1) on the surface of cultured human keratinocytes Norris, D.A.;Lyons, M.B.;Middleton, M.H.;Yohn, J.J.;Kashihara-Sawanu, M.
  22. Photochem. Photobiol. v.15 Formation of thymine dimers in mammalian skin by ultraviolet radiation in vivo Pathak, M.A.;Kramer, D.M.;Gungerich, U.
  23. Biol. Trace. Elem. Res. v.34 Inhibitory effects of some natural products on metal-induced lipid oxidation in cooked fish Ramanathan, L;Das, N.P
  24. Mutat. Res. v.213 Suppressing effects of tannic acid on the frequencies of mutagen-induced sister-chromatid exchanges in mammalian cells Sasaki, Y.;Imanishi, H.(et al.)
  25. Biochem v.29 no.36 Secondary structure of mammalian 70-kilodalton Heat Shock cognate protein analyzed by circular dichroism spectroscopy and secondary structure Seth, S.;Krishnamurthy, R.;Lawrence, E.H.
  26. J. Invest. Dermatol. v.66 no.4 The role of langerhans cells in allergic contact hypersensitivity. A review of findings in man and guinea pigs Silberberg, I.;Baer, R.L.;Rosentnal, S.A.
  27. J. Immunol. v.130 no.6 Alterations in lymphocyte homing patters within mice exposed to ultraviolet radiation Spangrude, G.J.;Bernhard, E.J.;Ajioka, R.S;Daynes, R.A.
  28. J. Lab. Clin. Med. v.125 Comparison of neutrophil chemotactic factor release by human and rabbit alveolar macrophages in response to tannin exposure Specks, U.;Kreofsky, T.J.;Limper, A.H.(et al.)
  29. Proc. Natl. Acad. Sci. USA v.86 Heme oxygenase is the major 32 kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite Stephen, M.K.;Rex, M.T.
  30. J. Immunol. v.121 no.5 Immunologic funtions of Ia-bearing epidermal langerhans cells Stingl, G.;Katz, S.I.;Clement, L.(et al.)
  31. Proc. Natl. Acad. Sci. v.76 Electrophoretic transfer of proteins from polycacylamide gels to nitrocellulose sheets : procedure and some applications Towin, H.
  32. Arch. Environ. Contam. Toxicol. v.20 Role of antioxidants and scavengers on argemone oil induced toxicity in rats Upreti, K.K.;Das, M.;Khanna, S.K.
  33. Carcinogenesis v.12 Protection against ultraviolet B radiation-induced photocarcinogenesis in hairless mice by green tea polyphenols Wang, Z.Y.;Agarwal, R.(et al.)
  34. Triangle v.26 Cellular interaction and skin the epidermis as an immune organ Wolff, K.;Stingl, G.
  35. Br. J. Dermatol. v.95 The sunburn cell in mouse skin : preliminary quantitative studies on its production Woodcock, A.;Magnus, I.A.