The Korean Journal of Physiology and Pharmacology
- Volume 2 Issue 4
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- Pages.461-469
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- 1998
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
Pharmacological Characterization of Synthetic Tetrahydroisoquinoline Alkaloids, YS 51 and YS 55, on the Cardiovascular System
- Chang, Ki-Churl (Department of Pharmacology, and Cardiovascular Research Institute, College of Medicine, Gyeongsang National University) ;
- Kang, Young-Jin (Department of Pharmacology, and Cardiovascular Research Institute, College of Medicine, Gyeongsang National University) ;
- Lee, Young-Soo (Department of Pharmacology, and Cardiovascular Research Institute, College of Medicine, Gyeongsang National University) ;
- Chong, Won-Seog (Department of Pharmacology, and Cardiovascular Research Institute, College of Medicine, Gyeongsang National University) ;
- Choi-Yun, Hey-Sook (Natural Product Research Institute, Seoul National University) ;
- Lee, Duck-Hyong (Department of Chemistry, Sogang University) ;
- Ryu, Jae-Chun (Korea Institute of Science and Technology)
- Published : 1998.08.21
Abstract
Tetrahydroisoquinoline (THI) alkaloids can be considered as cyclized derivatives of simple phenylethy-lamines, and many of them, especially with 6,7-disubstitution, demonstrate relatively high affinity for catecholamines. Two -OH groups at 6 and 7 positions are supposed to be essential to exert ?
Keywords
- Tetrahydroisoquinoline;
- ${\alpha}_1-adrenoceptor$;
- Guinea pig papillary muscle;
- Rat aorta;
- YS 51;
- YS 55;
- Cytosolic $Ca^{2+}$