Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지

Acute Subcutaneous Toxicity of DWP-311 in Rats

랫드에 대한 DWP-311의 급성피하독성시험

  • Kwack, Seung-Jun (Division of Toxicology, School of Pharmacy, Sungkyunkwan University) ;
  • Kim, Hyung-Sik (Division of Toxicology, School of Pharmacy, Sungkyunkwan University) ;
  • Chun, Sun-Ah (Division of Toxicology, School of Pharmacy, Sungkyunkwan University) ;
  • Lim, So-Young (Division of Toxicology, School of Pharmacy, Sungkyunkwan University) ;
  • Park, Hyun-Sun (Division of Toxicology, School of Pharmacy, Sungkyunkwan University) ;
  • Han, Ha-Su (Division of Toxicology, School of Pharmacy, Sungkyunkwan University) ;
  • Hong, Chae-Young (Division of Toxicology, School of Pharmacy, Sungkyunkwan University) ;
  • Ahn, Mi-Young (Division of Toxicology, School of Pharmacy, Sungkyunkwan University) ;
  • Lee, Byung-Mu (Division of Toxicology, School of Pharmacy, Sungkyunkwan University)
  • 곽승준 (성균관대학교 약학대학 독성학교실) ;
  • 김형식 (성균관대학교 약학대학 독성학교실) ;
  • 천선아 (성균관대학교 약학대학 독성학교실) ;
  • 임소영 (성균관대학교 약학대학 독성학교실) ;
  • 박현선 (성균관대학교 약학대학 독성학교실) ;
  • 한하수 (성균관대학교 약학대학 독성학교실) ;
  • 홍채영 (성균관대학교 약학대학 독성학교실) ;
  • 안미영 (성균관대학교 약학대학 독성학교실) ;
  • 이병무 (성균관대학교 약학대학 독성학교실)
  • Published : 1998.09.01
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Abstract

The acute toxicity of DWP-311 was investigated in Sprague-Dawley rats. DWP-311 was subcutaneously administratered at dose levels of 595, 1,070, 1,930, 3,470, and 6,250mg/kg. In this study, we daily examined numbers of deaths, clinical signs, body weights, and pathological examinations for 7 days after administration of DWP-311. The results indicate that DWP-311 did not show any toxic effect in rats and the oral $LD_{50}$ value was over 6,250mg/kg in Sprague-Dawley rats.

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