Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지

Acute Toxicity and Four-week Intravenous Toxicity Studies of Intralipidos

Intralipidos에 대한 급성독성 및 4주간 정맥 내 반복투여 독성시험

  • Li, Guang-Xun (Department of Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Che, Jeong-Hwan (Department of Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Kang, Byeong-Cheol (Department of Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Lee, Won-Woo (Department of Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Ihm, Jong-Hee (Department of Public Health, College of Veterinary Medicine, Seoul National Universi) ;
  • Jung, Ji-Yun (Department of Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Yi, Beoung-Hi (Department of Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Nam, Jeong-Seok (Department of Public Health, College of Veterinary Medicine, Seoul National University) ;
  • Park, Jae-Hak (Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University) ;
  • Lee, Yong-Soon (Department of Public Health, College of Veterinary Medicine, Seoul National University)
  • 이광훈 (서울대학교 수의과대학 공중보건학교실) ;
  • 제정환 (서울대학교 수의과대학 공중보건학실) ;
  • 강병철 (서울대학교 수의과대학 공중보건학실) ;
  • 이원우 (서울대학교 수의과대학 공중보건학실) ;
  • 임종희 (서울대학교 수의과대학 공중보건학실) ;
  • 정지윤 (서울대학교 수의과대학 공중보건학실) ;
  • 이병희 (서울대학교 수의과대학 공중보건학실) ;
  • 남정석 (서울대학교 수의과대학 공중보건학실) ;
  • 박재학 (서울대학교 수의과대학 실험동물의학교실) ;
  • 이영순 (서울대학교 수의과대학 공중보건학실)
  • Published : 1998.09.01
Download PDF
⟨ Previous Next ⟩

Abstract

This sutdy was carried out to investigate the acute toxicity and foru-week intravenous toxicity of the intralipidos in rats and rabbits. The acute toxicity study of Intralipidos was performed in Spragur-Dawley (SD) rats. Intralipidos was administered by intravenous to maximum dose 200 ml/kg. $LD_{50}$ of intralipidos was found 139.5ml/kg and 153.8ml/kg in male female SD rats. Four-week toxicity of intralipidos using New Zealand White Rabbit and SD rats. The Rabbit and Rats were administered by intravenous seven days per week for 28 days, with dosage of 15, 6, 2 ml/kg/day and 20, 6, 2ml/kg/day, respectively. Animals treated with intralipidos did not cause any death and show any clinical signs. They did not show any significant changes of body weight, feed uptake and water consumption. They were not significantly different from the control group in urinalysis, ocular examination hematological, serum biochemical value and histopathological examination. Therefore, Intralipidos was not indicated to have any toxic effect in the Rabbits and Rats, when it was administrated by intravenous below the dosage 15ml/kg/day and 20 ml/kg/day for four weeks.

Keywords