The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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Selective Cytotoxicity of a Novel Platinum (II) Coordination Complex on Human Gastric Cancer Cell Lines and Normal Kidney Cells

  • Jung, Jee-Chang (Departments of Pharmacology, School of Medicine, Kyung Hee University) ;
  • Kim, Young-Kyu (Departments of Pharmacology, School of Medicine, Kyung Hee University) ;
  • Yim, Sung-Vin (Departments of Pharmacology, School of Medicine, Kyung Hee University) ;
  • Park, Seung-Joon (Departments of Pharmacology, School of Medicine, Kyung Hee University) ;
  • Chung, Joo-Ho (Departments of Pharmacology, School of Medicine, Kyung Hee University) ;
  • Chang, Sung-Goo (Departments of Urology, School of Medicine, Kyung Hee University) ;
  • Lee, Kyung-Tae (Department of Biochemistry, College of Pharmacy, Kyung Hee University) ;
  • Rho, Young-Soo (Department of Pharmacochemistry, College of Pharmacy, Kyung Hee University)
  • Published : 1999.06.21
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Abstract

We have synthesized novel platinum (II) coordination complex containing cis-1,2-diaminocyclohexane (DACH) as a carrier ligand and 1,2-bis(diphenylphosphino)ethane (DPPE) as leaving group. Furthermore, nitrate was added to improve the water-solubility. A new series of [Pt(cis-DACH)(DPPE)] $2NO_3(PC)$ was evaluated its antitumor activity on various MKN-45 human gastric adenocarcinoma cell-lines and normal primary cultured kidney cells. The new platinum complex demonstrated high efficacy in the cytotoxicity on MKN-45 cell-lines as well as adriamycin-resistant (MKN-45/ADR) and cisplatin-resistant (MKN-45/CDDP) cells. The cytotoxicities of PC were found quite less than those of cisplatin in rabbit proximal renal tubular cells, human renal cortical cells and human renal cortical tissues using MTT assay, $[^3H]-thymidine$ uptake and glucose consumption tests. Based on these results, this novel platinum (II) coordination complex, was considered as better a valuable lead for improving antitumor activities with low nephrotoxicities in the development of a new clinically available anticancer chemotherapeutic agents.

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