Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Antitoxic Effects of Palsun Brewing Water against Bacterial Endotoxin and Cadmium Induced Cytotoxicity

팔선양조용수의 세균내독소와 카드뮴에 대한 해독효과(II)

  • 한두석 (원광대학교 치과대학 구강해부학교실) ;
  • 김진선 (원광대학교 치과대학 구강해부학교실) ;
  • 한종현 (한의학전문대학원 약리학교실) ;
  • 이호섭 (원광대학교 치과대학 생리학교실) ;
  • 김지주 (전북 부안군 상서면 변산 팔선약주협회) ;
  • 강길웅 (원광대학교 치과대학 천연물학교실) ;
  • 백승화 (원광대학교 치과대학 천연물학교실)
  • Published : 2000.03.01
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Abstract

This study was carried out to evaluate antitoxic effects Palsun Brewing Water against cadmium by colorimetric methods. The antitoxic activity of Palsun Brewing Water in NIH-3T3 fibroblasts was evaluated by MTT ({3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-2H-tetrazoliumbromide} and SRB (sulforhodamine B protein) assays. The light microcopic study was carried out to observe morphological changes of the treated cells. These results were obtained as follows: The concentration of 10-2 mg/ml of Palsun Brewing Water was shown significant antitoxic activity against E. coli endotoxin and Salmonella endotoxin. The number of NIH-3T3 fibroblasts were antitoxin and tend to regenerate. These results suggest that Palsun Brewing Water retains a potential antitoxic activity.

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References

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