Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Dermal and Ocular Irritation Studies of Some Phthalates in Rabbits

Phthalate의 피부자극시험 및 안점막자극시험에 관한 연구

  • 이종권 (식품의약품안전청 국립독성연구소 독성부) ;
  • 김주환 (식품의약품안전청 국립독성연구소 독성부) ;
  • 이은희 (식품의약품안전청 국립독성연구소 독성부) ;
  • 김용규 (식품의약품안전청 국립독성연구소 독성부) ;
  • 홍진태 (식품의약품안전청 국립독성연구소 독성부) ;
  • 박기숙 (식품의약품안전청 국립독성연구소 독성부) ;
  • 안광수 (식품의약품안전청 국립독성연구소 독성부) ;
  • 정수연 (식품의약품안전청 국립독성연구소 독성부) ;
  • 이선희 (식품의약품안전청 국립독성연구소 독성부)
  • Published : 2001.06.01
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Abstract

Phthalates are widely used as plasticizers to impart softness and flexibility to normally rigid polyvinylchloride products. However, there are not much studies jar dermal and ocular irritation toxicity of phthalates. So we investigated the skin or eye irritation effect of some phthalates which was not reported. The primary skin irritation of diethyl phthalate (DEP), diisodecyl phthalate (DIDP), diisononyl phthalate (DINP), dipropyl phthalate (DPP) and dipropyl phthalate (DPrP) was studied. The ocular irritation of dibutyl phthalate(DBP), DIDP, DINP, DPP and DPrP was also studied. DEP, DIDP, DINP, DPP, and DPrP were found to be non-irritating to the skin of the test animals. DBP, DIDP, DINP and DPP were found to be non-irritating to the eye of the rabbits. DPrP caused the slight irritations to the eye in 1 or 2 days after treatment but irritation of the animals was soon recovered.

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