Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Comparison of Eye Irritation Potency with Skin Irritation and Cytotoxicity Potency of Anti-wrinkle Agents

주름방지용 화장품원료의 안점막 자극성과 피부자극성 및 세포독성과의 비교

  • 이은희 (식품의약품안전청 국립독성연구소) ;
  • 이종권 (식품의약품안전청 국립독성연구소) ;
  • 김주환 (식품의약품안전청 국립독성연구소) ;
  • 정경미 (식품의약품안전청 국립독성연구소) ;
  • 정해관 (식품의약품안전청 국립독성연구소) ;
  • 이선희 (식품의약품안전청 국립독성연구소) ;
  • 정수연 (식품의약품안전청 국립독성연구소) ;
  • 홍진태 (식품의약품안전청 국립독성연구소)
  • Published : 2001.06.01
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Abstract

In the present study, we examined eye irritation oj six anti-wrinkle agents (ascorbic acid, glycolic acid, all trans-retinoic acid, ginseng extract, retinol, EB). We also compared eye irritation with skin irritation and cytotoxicity in HaCaT cells by these agents. The highest eye irritation was found in glycolic acid, but all trans-retinoic acid showed the highest skin irritation. The rank of eye irritation was not correlated with the cytotoxicity of agents. This result shows that eye irritation potency by these agents were not correlated with skin irritation potency, and cytotoxicity in HaCaT cells.

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