Advances in Traditional Medicine

  • 제2권2호
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  • Pages.106-112
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  • 2002
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  • 2662-4052(pISSN)
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  • 2662-4060(eISSN)
경희대학교 융합한의과학연구소 (Kyung Hee Oriental Medicine Research Center)
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Magnoliae Cortex inhibits immediate-type allergic reactions

  • Shin, Tae-Yong (College of Pharmacy, Woosuk University) ;
  • Oh, Ro-Sa (College of Oriental Medicine, Wonkwang University) ;
  • Lee, Eon-Jeong (College of Oriental Medicine, Wonkwang University)
  • 발행 : 2002.08.30
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초록

The effect of aqueous extract of Magnoliae Cortex (Magnoliaceae) (MCAE) on the immediate-type allergic reaction was investigated. MCAE inhibited compound 48/80 induced systemic anaphylactic reaction in rats. MCAE (0.1 and 1 g/kg) also significantly inhibited local immunoglobulin E (lgE)-mediated passive cutaneous anaphylactic (PCA) reaction. MCAE (0.001 to 1 mg/ml) dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-dinitrophenyl (DNP) 1gE. Moreover, MCAE (0.01 to 1 mg/ml) had a significant inhibitory effect on anti-DNP IgE-mediated tumor necrosis $factor-{\alpha}$ $(TNF-{\alpha})$ production. These results indicate that MCAE inhibits immediate-type allergic reaction in vivo and in vitro.

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