Environmental Mutagens and Carcinogens (한국환경성돌연변이발암원학회지)

Korean Environmental Mutagen Society (한국환경성돌연변이발암원학회)
권호 표지

A Meta-Analysis on the Associations of Gly460Trp Polymorphism of the $\alpha$-Adducin Gene with Hypertension

  • Kang, Byung-Yong (Research Institute for Life Science, Sahmyook University) ;
  • Lee, Kang-Oh (Department of Life Science, Sahmyook University) ;
  • Bae, Joon-Seol (Seoulin Bioscience Institute, Seoulin Bioscience, Co., Ltd.) ;
  • Kim, Ki-Tae (Seoulin Bioscience Institute, Seoulin Bioscience, Co., Ltd.) ;
  • Kim, Jae-Hyun (Department of Health Science, College of National Science, Dongduk Womens University) ;
  • Ryu, Jae-Chun (Toxicology Laboratory, Korea Institute of Science and Technology) ;
  • Lee, Chung-Choo (School of Biological Science, Seoul National University, Laboratory of Biology, Gachon Medical School)
  • Published : 2002.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

Gly460Trp polymorphism of a-adducin gene has been reported to be associated with hypertension in some populations, and we, therefore, attempted to replicate this finding in Korean population. There were no significant differences in allele and genotype frequencies of Gly460Trp polymorphism in Korean normotensives and hypertensives, respectively. The meta-analysis revealed that the Mantel-Haenszel estimate of the odds ratio across the studies was 1.17 (95%CI 1.04-1.31), and that there was significant evidence against homogeneity of the odds ratio among the studies included (Breslow-Day test = 27.34, df = 9, p = 0.001). Although the meta- analysis appeared in favour of association between the Gly4601tf polymorphism of $\alpha$-adducin gene and hypertension, there was the considerable heterogeneity among the studies and the evidence is also rather borderline. Further comprehensive approaches are needed to resolve this debatable issue.

Keywords