Animal cells and systems

The Korean Society for Integrative Biology (한국통합생물학회)
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Isolation and Phylogeny of SINE-R Retroposons Derived from Human Endogenous Retrovirus HERV-K Family in Schizophrenia

  • Kim, Heui-Soo (Division of Biological Sciences, College of Natural Sciences, Pusan National University) ;
  • Crow, Timothy J. (Department of Psychiatry, Warneford Hospital, University of Oxford)
  • Published : 2002.03.01
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Abstract

SINE-R retroposons have been derived from human endogenous retrovirus HERV-K family and found to be hominoid specific. Both SINE-R retroposons and HERV_K family are potentially capable of affecting the expression of closely located genes. Using the genomic DNA from patients with schizophrenia, we identified 26 SINE-R retroposons and analyzed them with the sequences derived from the hominoid primates. The SINE-R retroposons from schizophrenia showed 89.7-96.6％ sequence similarities with the sequence of the schizo-cDNA clone that derived from postmortem tissue from the frontal cortex of an individual suffering from schizophrenial. Phylogenetic analysis using the neighbor-joining method revealed that the new SINE-R retroposons in schizophrenia have proliferated independently during hominid evolution. Such retroposons have great relevance to genomic change connected to human diseases. The data suggest that new SINE-R retroposons identified in schizophrenia deserve further investigation as potential leads on the understanding of neuropsychiatric diseases.

Keywords

References

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