Journal of Photoscience
- Volume 9 Issue 2
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- Pages.491-493
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- 2002
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- 1225-8555(pISSN)
Erythrodermic Actinic Reticuloid Is Characterized by the Overspill of Oligoclonal CD8+ Lymphocytes Responsive To Ultraviolet Irradiation
- Iwatsuki, Keiji (Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry) ;
- Ohtsuka, Mikio (Department of Dermatology, Fukushima Medical University School of Medicine) ;
- Matsui, Takashi (Department of Dermatology, Fukushima Medical University School of Medicine) ;
- Yamamoto, Takenobu (Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry) ;
- Fujii, Kazuyasu (Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry) ;
- Yamasaki, Osamu (Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry) ;
- Tsuji, Kazuhide (Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry)
- Published : 2002.08.01
Abstract
Erythrodermic actinic reticuloid (EAR) is a photosensitive disorder characterized by dense lymphocytic infiltration in the sun-exposed areas and an increased number of atypical lymphocytes in the peripheral blood. We have reported 2 patients with EAR with circulating atypical lymphocytes and photosensitivity to both ultraviolet (UV) B and A. Although no clonal proliferation of T-cells was observed in the peripheral blood, CD8+ cells were increased in number in an oligoclonal fashion. A number of proliferating CD8+ cells were small, but most cells expressed bcl-2. These findings suggest EAR is a photosensitivity dermatitis characterized by the overspill of oligoclonal CD8+ lymphocytes responsive to UV irradiation.