B16 흑색종 세포의 폐전이에 대한 소암산1의 억제효과

Inhibitory Effects of Soamsan1 on Lung Metastasis of B16 Melanoma Cells

  • 전병훈 (한의과대학 병리학교실) ;
  • 김원신 (원광대학교 자연과학대학 생명과학부)
  • Jeon Byung Hun (Department of Pathology, college of Oriental Medicine) ;
  • Kim Won Sin (Life Science Major, Division of Natural Science and Technology, Wonkwang University)
  • 발행 : 2002.12.01

초록

We have examined whether Soamsan 1 (SA 1) augment the inhibitory effect of oral administration of Soamsan (SA) on lung metastasis of mouse 816 melanoma cells. The inhibitory effect was slightly enhanced by increase in administration dosage of SA 1. SA 1 as well as SA inhibited effectively the lung metastasis regardless of the pretreatment with anti-mouseNK monoclonal antibody. However, in the case of 2-chloroadenosine-pretreated mice, the inhibitory effects of SA and SA 1 were decreased by 18 and 23%, respectively. In vitro stimulation of the mouse splenocytes with mitogens showed that SA or SA 1 significantly augmented the proliferation of mouse splenocytes. Especially, the activity was more prominent in the presence of a B cell mitogen. LPS than a T cell mitogen, Con A. These results suggest that oral administration of SA 1 or SA inhibited lung metastasis of B16 melanoma cells, possibly through a mechanism mediated by the activation of macrophages and B lymphocytes in the host immune system. However, SA 1 did not showed more significant augment of the activation of immune system than SA.

키워드

참고문헌

  1. 東醫治療經驗集成 第7卷 肝膽道疾病
  2. Surg. Gynecol. Obstet. v.174 Patterns of recurrence after curative resection of carcinoma of the colon and rectum. Galandvick,S.;Wieand, H.,S.;Moertel, C, G.;Cha, S. S.;Fitzgibbons, R. J., Jr.;Premberton, J. H.;Wolff, B. G.
  3. Cancer Res. v.56 Anti-invasive activity of ursolic acid correlates with the reduced expression of matrix metalloproteinase-9 (MMP-9) in HT1080 human fibroblastoma cells. Cha, H. J.;Bae, S. K.;Lee H. Y.;Sato, H.;Seiki, M.;Park, B. C.;Kim, K. W.
  4. Kor J Oriental Pathology v.13 no.2 Anticancer effect of cinnamaldehyde purified from cinnamoni cortexextract on F9 teratocarcinoma stem cells. Beak, E. K.;Kim, D. K.;Lee, J. W.;Kim, W. S.;Jeon, B. H.;Woo, W. H.;Jeong, W. Y.
  5. Arch. Pharm. Res. v.21 no.2 Synthesis and in vitro cytotoxity of cinnamaldehydes to human solid tumor cells. Kwon B. M.;Lee, S. H.;Choi, S. U.;Park, S. H.;Lee, C. O.;Cho, Y. K.; Sung, N. D.;Bok,S.H.
  6. J Toxicol Pub Health v.15 Effects of Rhus verniciflua Stokes (RVS) on the plasma level of cholesterol and tumor growth in mouse. Lee, J. C;Jung, H. Y.;Lim, K. T.
  7. Ph.D. thesis, Biological activity of urushiol and flavonoids from Lac tree (Rhus verniciflua Stokes). Jung, N. C.
  8. Experientia v.36 Isolation of biologically active alkaloids from Korean mistletoe Viscum album, coloratum. Khwaja, T. A.;Varven, J. C.;Pentecost, S.;Pande, H.
  9. Kor J Oriental Pathology v.12 Antitumor and immune modulatory effects of Bojungtang in ICR mice. Ha, J. Y;Lim, H. J.
  10. Kor J Oriental Pathology v.12 Antitumor and immune modulatory effects of Gagamleejungtang in BALB/c mice. Ha, J. Y;Lee, H.
  11. Jpn. J. Cancer Res. v.89 Oral administration of a Kampo (Japanese herbal) medicine Juzen-taiho-to inhibits liver metastasis of colon 26-L5 carcinoma cells. Ohnishi, Y.;Fujii, H.;Hayakawa, Y.;Sakukawa, R.;Yamamura, Y.; Sakamoyo, T.;Tsukada, K.;Fujimaki, M.;Nunome, S.;Komatsu, Y.;Saiki, I.
  12. Anticancer Res. v.20 Effect of interferon-$\alpha$A/D in combination with the Japanese and Chinese traditional herbal medicine Juzen-taiho-to on lung metastasis of murine renal cell carcinoma. Muraishi, Y.;Mitani, N.;Yamamura, T.;Fuse, H.;Saiki, I.
  13. Immunophar.Immunotoxi. v.24 Modulation of antigen-specific immune response by the oral administration of a traditional medicine, bo- yang-hwan-o-tang. Kim, E. H.;Lee, J. C.;Kim, J.;Son Y. O.;Chung, G. H.;Jang, Y. S.
  14. Kor J Oriental Pathology v.15 no.6 Oral administration of a Korean Hebal Medicines, Soamsan, inhibits lung metastasis of mouse B16 melanoma cells. Ju, S. M.;Yang, H. H.;Woo, W. H.;Jeong, W. Y.;Jo, W. J.;Lee, K. Y.; Jeon, B. H.;Kim, W. S.
  15. Cancer Res. v.45 Marcrophages and metastasis- A biological approach to cancer theraphy: presidental adress. Fidler, I. J.
  16. Cancer Metast. Rev. v.1 Role of natural killer cells and control of cancer metastasis. Hanna, N.
  17. J. Immunolo. v.127 Invitro effects of anti-asialo GM1. Habu, S.;Fukui, H.;Shimamura, K.;Kasai, M.;Nagai, Y.;Okumura, K.;Tamaoki, N.
  18. Br. J. Cancer v.60 Antimetastic effects of synthetic polypeptides containing repeated structures of the cell adhesive Arg-Gly-Asp (R-G-D) and Tyr-Ile-Gly-Ser-Arg (YIGSR) sequences. Saiki, I.;Murata, J.;Iida, J.;Sakurai, T.;Nishi, N.;Matsuno, K.;Azuma, I.