Study on the Effect of Radix polygoni Multiflori on Cultured Mouse Cerebral Neurons Damaged by Organic Mercury

하수오가 유기수은으로 손상된 생쥐의 배양대뇌신경세포에 미치는 영향에 관한 연구

  • Yoo Kyo Sang (Department of School of Medicine, Wonkwang University) ;
  • Lee Yong Suk (Department of School of Medicine, Wonkwang University) ;
  • Son Young Woo (Department of School of Medicine, Wonkwang University) ;
  • Hong Gi Youn (Department of School of Medicine, Wonkwang University)
  • Published : 2002.12.01

Abstract

To investigate the neurotoxic effect of organic chloride on cultured mouse cerebral neurons, cytotoxic effect was measured by MTT assay after cultured cerebral neurons were incubated with various concentrations of methyl mercuric chloride(MMC) for 24 hours. The protective effect of Radix Polygoni Multiflori(RPM) on MMC-induced neurotoxicity was also examined in these cultures. MMC decreased cell viability of cultured mouse cerebral neurons remarkably in a dose- and time-dependent manners. In protective effect of RPM it was remarkably effective in blocking the neuroxicity induced by MMC. From aboved the results, it is suggested that MMC induce neurotoxicity, and the herba extract, RPM is very effective in preventing MMC-induced cytotoxicity on cultured mouse cerebral neurons.

Keywords

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