동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제16권6호
  • /
  • Pages.1170-1176
  • /
  • 2002
  • /
  • 1738-7698(pISSN)
  • /
  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
권호 표지

화담청화탕이 acetic acid로 유발된 흰쥐 위궤양 점막의 내분비세포와 점액의 조직화학적 변화

The Changes of Mucin and Endocrine cells of Mucosa of Acetic Acid-Induced Gastric Ulcer after Administration of Whadamcheongwha-tang Extract in Rat

  • 강경래 (우석대학교 한의과대학 원전의사학교실) ;
  • 육상원 (우석대학교 한의과대학 원전의사학교실) ;
  • 고형근 (우석대학교 한의과대학 병리학교실) ;
  • 이광규 (우석대학교 한의과대학 병리학교실) ;
  • 이창현 (우석대학교 한의과대학 해부학교실)
  • Kang Gyung Rae (Department of Classics, College of Oriental Medicine, Woosuk University) ;
  • Yuk Sang Won (Department of Classics, College of Oriental Medicine, Woosuk University) ;
  • Ko Hyoung Gon (Department of Oriental Pathology, College of Oriental Medicine, Woosuk University) ;
  • Lee Kwang Gyu (Department of Oriental Pathology, College of Oriental Medicine, Woosuk University) ;
  • Lee Chang Hyun (Department of Anatomy, College of Oriental Medicine, Woosuk University)
  • 발행 : 2002.12.01
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초록

We examined the effects of Whadamcheongwha-tang(WDCWT) extract on the acetic-acid induced antigastric ulcer in rats. These experiments investigated the numerical changes of gastrin and histamine secreting cells of the gastric mucosa by immunohistochemical method, and the changes of mucin of gastric mucosa by PAS-AB stain methods after the oral administration of WDCWT extract(1.0ml/day) and omeprazole(0.2mg/day) for 1, 3 and 6 weeks. The result are as follows; 1. When WDCWT extract was administrated for 1, 3, 6 weeks, in result, gastrin secreting cells in gastric mucosa were increased compared to the control group. 2. When WDCWT extract was administrated for 1, 3, 6 weeks, in result, the density of immunoreactive gastrin cells was increased compare to the control group. 3. When WDCWT extract was administrated for 1, 3, 6 weeks, in results, the changs of mucosal thickness stained by PAS/PAS-AB was increased compared to the control group. 4. When WDCWT extract was administrated for 1, 3, 6 weeks, in results, the density of PAS stain was decreased compare to control group, but density of AB stain was increased compare to control group. The results suggest that WDCWT extract inhibits a gastric acid secretion in rat gastric mucosa, and is useful in the treatment of the hyperacidity and gastric ulcer.

키워드

참고문헌

  1. 동국대학교석사학위논문 조잡$\cdot$呑酸에 미치는 消食淸鬱湯의 효능에 대한 연구 姜允皓
  2. 비계내과학 柳基遠(외10인)
  3. 東醫處方大全 李順東
  4. Principles of internal medicine Isselbacher, K.J.
  5. The stomach as an endocrine organ. The somatostatin cell as a local modulator of gastric function. Schubert, M.L.;Makhlouf G.M.; Hakanson R;Sundler F(ed.)
  6. Regul Pept v.20 The effect of somatostatin on baseline and stimulated acid secretion and vascular histamine release from the totally isolated vasculary perfused rat stomach. Sanvic, A.K.;Waldum, H.L.
  7. The gut as an endocrine organ. v.8 Somatostatin. Shulkes, A.;Fuller P;Shulkes A(eds)
  8. Pharmacology v.40 Effects of histamine on protein and glycoprotein production of isolated pig gastric mucosal cells. Heim, H.K.;Oestmann, A.;Sewing, K.F.
  9. Gastroenterology v.102 Regulation of canine gastric mucin synthesis and phospholipid secretion by acid secretagogues. Scheiman, J.M.;Kraus, E.R.;Boland, C.R.
  10. Annu Rev Physiol v.57 Mucin biophysics. Bansil, R.;Stanley, E.;Tsukahara, M.;La Mont, J.F.
  11. Am J Anat v.161 Comparative histochemical study of alimentary tracts with special reference to the mucous neck cells of the stomach. Suganuma, T.;Katsuyama, T.;Tsukahara, M.;Tatematsu, M.; Sakakura, Y.;Murata, F.
  12. Nature v.290 Substituted benzimidazoles inhibit gastric acid secretion by ($H^{++}K^+$) ATPase. Fellenius, E.;Berglindh, T.;Sachs, G.
  13. Gastroenterology v.85 Inhibition of gastric acid secretion by omeprazole in the dog and rat. Larsson, H.;Carlsson, E.;Junggren, U.
  14. Dig Dis Sic v.29 Effect of a proton pump inhibitor, omeprazole, on gastric secretion and gastric and duodenal ulcers or erosions in rats. Yamamoto, O.;Okada, S.
  15. Gastroenterology v.85 Dose-response study of omeprazole on meal-stimulated gastric acid secretion and gastrin release. Londong, W.;Longdong, V.;Cederberg, C.;Steffen, H.
  16. New Engl J Med v.310 Omeprazole in Zollinger- Ellison syndrome. Lamer, C.B.H.W.;Lind, T.;Moberg, S.
  17. Gut v.23 Antral gastrin-producing G-cell and somatostatin-producing D-cell in different states of gastric acid secretion. Arnold, R.;Hulst, M.V.;Neuhof, C.H.;Schwarting, H.;Becker, H.D.; Creutzfeldt, W.
  18. Eur J Clin Invest v.1 Gastrin and G-cell in the antral mucosa of patients with pernicious anaemia. acromegaly and hyperparathyroidism and in a Zollinger-Ellison tumour of the pancreas. Creutzfeldt, W.;Arnold, R.;Creutzfeldt, W.;Feurle, G.;Ketterer, H.
  19. Scand J Gastroent v.108 no.20 Toxicological studies on omeprazole. Ekman, L.;Hansson, E.;Havu, N.;Carlsson, E.;Lundberg, C.
  20. Scand J Gastroenterol Suppl v.118 Pharmacology and toxicology of omeprazole--with special reference to the effects on the gastric mucosa. Carlsson, E.;Larsson, H.;Mattsson, H.;Ryberg, B.;Sundell, G.
  21. Digestion v.35 no.1 Effect of short- and long-term feeding of omeprazole on rat gastric endocrine cells. Creutzfeldt, W.;Stockmann F.;Conlon, J.M.
  22. 東醫寶鑑 許浚
  23. Jap J Pharmacol v.19 A new method for the production of chronic gastric ulcer in rats and the effect of several drugs on its healing. Takagi, K.;Okabe, S.;Saziki, R.
  24. Hoeber Med. Div. Staining methods. McManus, J.A.;Mowry, R.W.
  25. 完譯中藥大辭典 신민교(외)
  26. Gastroenterology v.68 Gastrin cell hyperplasia in rats with chronic antral stimulation. Lehy, T.;Viollemot, N.;Dubrasquet, M.;Dufougeray, F.
  27. 東醫生理病理學會誌 v.15 二陳湯 煎湯液이 흰쥐 위의 gastrin, histamine, somatostatin 면역반응세포에 미치는 영향 崔正宇(외4인)
  28. Rc Gastroent v.7 The gastrin- producing cells under normal and pathological conditions. Creutzfeldt, W.;Creutzfeldt, C.;Arnold, R.
  29. Comp Biochem Pharmacol v.46 Stimulation of mucus glycoprotein biosynthesis in rat gastric mucosa. Ichikawa, T.;Ishiharam K.;Saigenjim K.;Hotta, K.
  30. Biochem Biophys Acta v.621 Isolation and partial characterization of rat gastric mucus glycoprotein. Spee-Brand, R.;Strous, G.J.A.M.;Kramer, M.F.
  31. J Biohem v.103 Two types of rat gastric mucus glycoprotein subunits. Ohara, S.;Ishihara, K.;Hotta, K.
  32. Comp Biochem Physiol. A Physiol v.104B Comparison of the mucus glycopro- teins present in the different layers of rat gastric mucosa. Ishihara, K.;Hotta, K.
  33. Am J Physiol v.263 Gastrin induction of histamine release from primary cultures of canine oxyntic mucosal cells. Chuang, C.N.;Tanner, M.;Chen, M.C.Y.;Davidson, S.;Soll, A.H.
  34. Am J Physiol v.260 CCK-B(gastrin)receptor regulates gastric histamine release and acid secretion. Sandvik, A.K.;Waldum, H.L.
  35. Acta Physiol Scand v.131 Mechanism of stimulation of acid production in parietal cells isolated from the pig gastric mucosa. Mardh, S.;Song, Y.H.;Carlsson, C.;Bjorkman, T.
  36. Dig Dis Sci v.33 Prostaglandin(PG)E2 receptors on porcine chief cells. Sewing, K.F.R.;Beinborn, M.
  37. Dig Dis Sci v.37 Role of prostaglandine E2 in cholinergic mediated glycoprotein synthesis in canine antrum. Yoshimura, K.;Kraus, E.R.;Shimakura, S.;Scheiman, J.M.;Boland, C.R.
  38. Methods Find Exp Clin Pharmacol v.14 Omeprazole-induced changes in gastric mucus secretion. Guslandi, M.;Franceschi, M.;Fanti, L.;Pellegrini, A.;Tittobello, A.
  39. Aliment Pharmacol Ther v.10 The effect of omeprazole on gastric juice viscosity, pH and bacterial counts. Goddard, A.F.;Spiller, R.C.
  40. Digestion v.56 Mechanism of protection by omeprazole against experimental gastric mucosal damage in rats. Blandizzi, C.;Gherardi, G.;Marveggio, C.;Natale, G.;Carignani, D.; Del Tacca, M.