Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Immuno-Regulatory Effects of Cheongsimondam-tang

청심온담탕의 면역조절 효과

  • Park Min Chul (Department of Pathology, College of Oriental Medicine, Woosuk University) ;
  • Jin Jae Ho (Department of Pathology, College of Oriental Medicine, Woosuk University) ;
  • Jung Han Sol (Department of Pathology, College of Oriental Medicine, Woosuk University) ;
  • Lee Kwang Gyu (Department of Pathology, College of Oriental Medicine, Woosuk University)
  • 박민철 (우석대학교 한의과대학 병리학교실) ;
  • 진재호 (우석대학교 한의과대학 병리학교실) ;
  • 정한솔 (우석대학교 한의과대학 병리학교실) ;
  • 이광규 (우석대학교 한의과대학 병리학교실)
  • Published : 2002.12.01
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Abstract

The purpose of this research was to investigate the effect of Cheongsimondam-tang(CSODT) on the activity of immune cell and anti-carcinogenic effect of mouse leukemia cell. The addition of CSODT(1 ㎍/ml) enhanced the proliferation of cultured-splenocytes and thymocytes. And also administration of CSODT(500 ㎍/kg) accelerated subpopulation of splenic and thymic T lymphocytes especially CD4/sup +/-T/sub H/ cells in BALB/c mice. CSODT treatment decreased cell proliferation and increased apoptotic cell death of cultured-L1210 leukemia cells, and induced apoptosis in addition to decreased mitochondrial transmembrane potential (ΔΨm) of transplanted-L1210 cells in vivo. These results suggest that CSODT have a cellular immuno-regulatory effect and anti-cancer property action.

Keywords

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