Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Cytotoxic and Antimicrobial Activities of Bioactive Monoterpenophenols

  • Oh In Kio (Department of Environmental Hygiene, Wonkwang Health Science College) ;
  • Lee Hyun Ok (Department of Dental Hygiene, Wonkwang Health Science College) ;
  • Ahn Jong Woong (Medicinal Science Division, Korea Research Institute of Chemical Technology) ;
  • Kim Hyung Min (Department of Oriental Pharmacy, School of Pharmacy, Wonkwang University) ;
  • Shin Ji Hee (Department of Herbal Resources, Professional Graduate School of Oriental Medicine Wonkwang University) ;
  • Lim Jin A (Department of Herbal Resources, Professional Graduate School of Oriental Medicine Wonkwang University) ;
  • Chun Hyun Ja (Department of Herbal Resources, Professional Graduate School of Oriental Medicine Wonkwang University) ;
  • Baek Seung Hwa (Department of Herbal Resources, Professional Graduate School of Oriental Medicine Wonkwang University)
  • Published : 2002.12.01
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Abstract

Compounds 1 - 12 were tested for their growth inhibitory effects against tumor cell lines using two different 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) and sulforhodamine B protein (SRB) assays and antimicrobial activity. The cytotoxic activity of methyl-4-[{(2E)-3,7-dimethyl-2,6-octadienyl}oxy]-3-methoxy benzoate (1) exhibit more active than that of 5-fluorouracil (11) on human oral epithelioid carcinoma (KB, ATCC No. OCL 17) cell lines. But this compound (1) on human skin melanoma (SK-MEL-3, HBT 69) cell lines shows less active than that of adriamycin (12). However, compound 9 showed the antimicrobial activity against S. epidermidis (MIC, 15.625 ㎍/㎖), S. aureus, C. albicans (MIC, 31.25 ㎍/㎖), S. mutans, S. typhimurium, P. putida (MIC. 125 ㎍/㎖) and P. aeruginosa (MIC, 500 ㎍/㎖).

Keywords

References

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