Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Inhibitory Effect of Omisodok-eum on the Secretion of NO in LPS-stimulated Mouse Peritoneal Macrophages

오미소독음이 마우스 복공 대식세포에서 NO의 분필과정에 미치는 영향

  • Park Hae Joon (Department of Oriental Medicine. Oriental Otorhinolaryngology & Dermatology Class, Graduate School, Dongeui University) ;
  • Yoon So Won (Department of Oriental Medicine. Oriental Otorhinolaryngology & Dermatology Class, Graduate School, Dongeui University) ;
  • Yoon Jung Won (Department of Oriental Medicine. Oriental Otorhinolaryngology & Dermatology Class, Graduate School, Dongeui University) ;
  • Yoon Hwa Jung (Department of Oriental Medicine. Oriental Otorhinolaryngology & Dermatology Class, Graduate School, Dongeui University) ;
  • Ko Woo Shin (Department of Oriental Medicine. Oriental Otorhinolaryngology & Dermatology Class, Graduate School, Dongeui University)
  • 박혜중 (동의대학교 한의과대학 안이비인후피부과교실) ;
  • 윤화정 (동의대학교 한의과대학 안이비인후피부과교실) ;
  • 윤정원 (동의대학교 한의과대학 안이비인후피부과교실) ;
  • 윤소원 (동의대학교 한의과대학 안이비인후피부과교실) ;
  • 고우신 (동의대학교 한의과대학 안이비인후피부과교실)
  • Published : 2002.10.01
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Abstract

Inflammation is localized response to foreign substance such as bacteria or in some instance to internally produced substances and has relation with immunity system. The macrophages plays a role in the development of the Iymphohaemopoietic system before and after birth, as well as in the natural and acquired immune responses of adult to immunogens, including infectious agents. NO have been suggested to play an important role in endotoxin-mediated shock and imflammation. In this study, we investigated the effect of Omisodok-eum on the production of NO. The Omisodok-eum inhibited the secretion of NO in LPS-stimulated mouse peritoneal macrophages, without affecting cell viability. The protein level of inducible nitric oxide synlhase(iNOS) in peritoneal macrophages was also decreased by Omisodok-eum. These results suggest that Omisodok-eum suppresses the endotoxin-induced inflammatory responses through inhibiting the production of NO

Keywords

References

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