Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effect of Yonggak-san on the Immuno-regulatory and Apoptosis of Leukemia cells

용각산의 면역조절 및 백혈병세포의 아폽토시스에 미치는 효과

  • Oh Chan Ha (Division of Biotechnology, Woosuk University) ;
  • Kwon Jin (Department of Health Administration. Kunjang College) ;
  • Lee Kwang Gyu (College of Oriental Medicine. Woosuk University)
  • 오찬호 (우석대학교 생명공학부) ;
  • 권진 (군장대학교 보건행정과) ;
  • 이광규 (우석대학교 한의과대학)
  • Published : 2002.10.01
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Abstract

The purpose of this research was to investigate the effect of Yonggak-san (YGS) on the immune reaction and apoptosis of leukemia cells. Administration of YGS(500 mg/kg) enhanced proliferation of splenocytes, thymocytes and mesenteric lymph node cells, and also YGS accelerated subpopulation of splenic Band T, thymic T and mesenteric lymph node-T lymphocytes, especially significantly increased CD4+-TH cells in BALB/c mice. YGS accelerated phagocytic activity and production of nitric oxide in peritoneal macrophages. YGS induced apoptosis of transplanted-L1210 cells in vivo, increased apoptotic cell death of cultured-L1210 and/or Molt4 human leukemia cells, decreased of mitochondrial transmembrane potential of both cells in vitro. These results suggest that YGS have an immune-regulatory effect and anti-cancer property.

Keywords

References

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