Effect of Ohjeoksan-Decoction on Brain Metal Level in Rats

오적산을 투여한 흰쥐의 뇌중 금속농도변화에 관한 연구

  • Min Dae Ki (Department of Circulatory Internal Medicine. College of Oriental Medicine, Sangji University) ;
  • Han Seong Nim (Hanseong medical clinic) ;
  • Ko Seong Gyu (Department of Circulatory Internal Medicine. College of Oriental Medicine, Sangji University)
  • 민대기 (상지대학교 부속한방병원 심계내과학교실) ;
  • 한성님 (한성의원) ;
  • 고성규 (상지대학교 부속한방병원 심계내과학교실)
  • Published : 2002.10.01

Abstract

This study was to investigate the metal accumulation from Ohjeoksan-Decoction to rat brain(Sprague Dawley). 1. In Control group, each metal concentration was within 26.65mg/kg, and in each experimental groups, was within 28.39mg/kg. And, there were no significant metal concentration between control and experimental groups. Exceptionally, Cr and Ni level of control group was lower than experimental groups significantly. (p<0.05) and Cr and Ni level of experimental I group was lower than other experimental groups too.(p<0.05). But, Pb level of control group was higher than experimental groups significantly.(p<0.05) Pb level of experimental I group was higher than other experimental groups(p<0.01). 2. In non-hazardous, hazardous and total metal concentration, there was no increase tendency in brain according to the high dose of OD(Ohjeoksan-Decoction) intake. Reversely, in experimental groups, hazardous metal concentration was decrease by high OD intake.(p<0.05). 3. Correlation among each metal in brain was various in each groups. Briefly under the intake of Ohjeoksan-Decoction, that is very busy herb prescription, this study was defined within safety in brain metal level by P.O. during 10 days. But, there should be a more research about Pb increase by high dose OD intake

Keywords

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