Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Particle Size Analysis of Cadmium Aerosol for Cadmium Inhalation Toxicology Study (766ppm Cadmium Nebulizing Solution)

카드뮴의 흡입독성 연구를 위해 설계된 에어로졸 발생장치에서 발생된 카드뮴 에어로졸의 입경분석(766ppm 카드뮴 네뷸라이징 용액)

  • Jeung Jae Yeal (The Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Milton Donald K. (Department of Environmental and Occupational Health Program, School of Public Health, Harvard University. USA) ;
  • Kim Tae Hyeung (Department of Environmental Engineering, Changwon National University) ;
  • Lee Jong Young (Department of Preventive Medicine. School of Medicine, Kyungpook National University) ;
  • Jahng Doo Sub (Institute of lndustrial Ecological Sciences, University of Occupational and Environmental Health) ;
  • Kang Sung He (The Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Song Young Sun (The Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee Ki Nam (The Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 정재열 (원광대학교 한의학전문대학원 제3의학과) ;
  • 도날드밀턴 (하버드대학교 대학원 환경 및 산업보건학과) ;
  • 김태형 (창원대학교 환경공학과) ;
  • 이종영 (경북대학교 의과대학 예방의학교실) ;
  • 장두섭 (일본 산업의과대학교 산업생태학연구소) ;
  • 강성호 (원광대학교 한의학전문대학원 제3의학과) ;
  • 송용선 (원광대학교 한의학전문대학원 제3의학과) ;
  • 이기남 (원광대학교 한의학전문대학원 제3의학과)
  • Published : 2002.10.01
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Abstract

Ultrasonic nebulizer with the application of new engineering methodology and the design of electronic circuit and 766ppm Cd nebulizing solution were used to generate cadmium aerosol for inhalation toxicology study. The results of particle size analysis for cadmium aerosol were as following. The highest particle counting for source temperature 20℃ was 43.449 x 10³ in inlet temperature 250℃ and particle diameter 0.75㎛. The highest particle counting for source temperature 50℃ was 43.211 x 10³ in inlet temperature 100 ℃ and particle diameter 0.75㎛. The highest particle counting for source temperature 70℃ was 41.917x10³ in inlet temperature 250℃ and particle diameter 0.75㎛. The ranges of geometric mean diameter(GMD) were 0.677-1.009㎛ in source temperature 20℃, 0.716-0.963㎛ in source temperature 50℃, and 0.724-0.957㎛ in source temperature 70℃. The smallest GMD was 0.677㎛ in source temperature 20℃ and inlet temperature 20℃. and the largest GMD was 1.009㎛ in source temperature 20℃ and inlet temperature 20℃. The ranges of geometric standard deviation(GSD) were 1.635-2.101 in source temperature 20℃. 1.676-2.073 in source temperature 50℃, and 1.687-2.051 in source temperature 70℃. The lowest GSD was 1.635 in source temperature 20℃ and inlet temperature 20℃, and the highest GSD was 2.101 in source temperature 20℃ and inlet temperature 200℃. Aerosol generated for cadmium inhalation toxicology study was polydisperse aerosol. The ranges of mass median diameter(MMD) were 1.399-5.270㎛ in source temperature 20℃. 1.593-4.742㎛ in source temperature 50℃, and 1.644-4.504㎛ in source temperature 70℃. The smallest MMD was 1.399㎛ in source temperature 20℃ and inlet temperature 20℃, and the largest MMD was 5.270㎛ in source temperature 20℃ and inlet temperature 200℃. Increasing trends for GMD, GSD, and MMD were observed with same source temperature and increase of inlet temperature. MMD for inhalation toxicology testing in EPA guidance is less than 4㎛. In our results. inlet temperature 20 and 50℃ in source temperature 20℃, and inlet temperature 20 to 150℃ in source temperature 50 and 70℃ were conformed to the EPA guidance. MMD for inhalation toxicology testing in OECD and EU is less than 3㎛. In our results, inlet temperature 20 and 50℃ in source temperature 20, 50, and 70℃ were conformed to the OECD and EU guidance.

Keywords

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