Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effect of Liuweidihuang-tang on Alcohol-induced Decrease in New Cell Formation in Rat Dentate Gyrus

  • Bahn Goon Ho (Department of Psychiatry, College of Medicine, Kyunghee University) ;
  • Yoon Doh Joon (Department of Psychiatry, College of Medicine, Kyunghee University) ;
  • Park Jin Kyung (Department of Psychiatry, College of Medicine, Kyunghee University) ;
  • Lee Taeck Hyun (Department of Physiology. College of Medicine, Kyunghee University) ;
  • Jang Mi Hyoon (Department of Physiology. College of Medicine, Kyunghee University) ;
  • Shin Min Chul (Department of Physiology. College of Medicine, Kyunghee University) ;
  • Kim Chang Ju (Department of Physiology. College of Medicine, Kyunghee University) ;
  • Paik Eun Kyung (Doorhii Oriental Medical Clinic) ;
  • Park Jae Hyung (Doorhii Oriental Medical Clinic) ;
  • Cho Son Hae (Oriental Medicine Research Institute, Kyungwon University) ;
  • Lee Choong Yool (Oriental Medicine Research Institute, Kyungwon University)
  • Published : 2002.10.01
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Abstract

Liuweidihuang-tang has been traditionally used for the treatment of delayed mental and physical development in children, complications of diabetes. and glomerulonephritis. In the present study, the effect of Liuweidihuang-tang on cell proliferation in the dentate gyrus of alcohol-intoxicated Sprague-Dawley rats was investigated via 5-bromo-2' -deoxyuridine (BrdU) immunohistochemistry. Alcohol administration was shown to decrease the number of BrdU-positive cells in the dentate gyrus, while Liuweidihuang-tang treatment increased new cell formation in the dentate gyrus under normal conditions and alcohol intoxication. It was thus demonstrated that aqueous extract of Liuweidihuang-tang exerts a protective effect against alcohol-induced decrease in new cell formation.

Keywords

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