Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effect of Astragali radix Extract on Acetaminophen-induced Hepatotoxicity in Mice

황기 추출액이 Acetaminophen으로 유발된 마우스의 간 손상에 미치는 영향

  • Lee Young Sun (Efficacy and Safety Research Center for Traditional Oriental Medicines, Kyungsan University, Kyongbuk Technopark) ;
  • Han Ok Kyung (Efficacy and Safety Research Center for Traditional Oriental Medicines, Kyungsan University, Kyongbuk Technopark) ;
  • Jean Tae Won (Efficacy and Safety Research Center for Traditional Oriental Medicines, Kyungsan University, Kyongbuk Technopark) ;
  • Lee Eun Sil (Efficacy and Safety Research Center for Traditional Oriental Medicines, Kyungsan University, Kyongbuk Technopark) ;
  • Kim Kwang Joong (College of Oriental Medicine, Kyungsan, University) ;
  • Park Chan Woo (Kyongju Oriental Hospital, Gyeongju) ;
  • Kim Hyo Jung (Efficacy and Safety Research Center for Traditional Oriental Medicines, Kyungsan University, Kyongbuk Technopark, College of Oriental Medicine, Kyungsan, University)
  • 이영선 ((재)경북테크노파크 경산대학교 한방생명자원특화센터 효능검증원) ;
  • 한옥경 ((재)경북테크노파크 경산대학교 한방생명자원특화센터 효능검증원) ;
  • 전태원 ((재)경북테크노파크 경산대학교 한방생명자원특화센터 효능검증원) ;
  • 이은실 ((재)경북테크노파크 경산대학교 한방생명자원특화센터 효능검증원) ;
  • 김광중 (경산대학교 한의과대학) ;
  • 박찬우 (경주한방병원) ;
  • 김효정 ((재)경북테크노파크 경산대학교 한방생명자원특화센터 효능검증원, 경산대학교 한의과대학)
  • Published : 2002.08.01
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Abstract

Astragali radix (AR) is one of the oldest and mast frequently used crude drug for traditional medicine in many Asian countries. This study designed to investigate the hepatoprotective effects of the aqueous extracted AR (ARE) against acetaminophen (APAP)-induced hepatic damage in ICR mice. APAP at the dose of 450 mg/kg i.p produced liver damage in ICR mice. Serum enzyme activities of alanine aminotransferase, aspartate aminotransferase and sorbitol dehydrogenese was dramatically decreased up to control level by pretreatment of ARE. However, hepatic glutathione level did not show a significant change between the tested groups. We also investigated TNF α mRNA gene expression on APAP-induced liver damage by RT-PCR. APAP dramatically induced TNF α mRNA gene expression in ICR mice. Pretreatment of mice with ARE led to a marked decrease of TNF α mRNA gene expression. These data indicate that 1) ARE has clearly revealed a hepatoprotective effect against APAP-induced hepatic damage in ICR mice, and 2) the protective effect of ARE may be, in part, associated with the regulation of TNF α mRNA gene expression.

Keywords

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