Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Study on the Effect of Flos Carthami on Cultured Osteoblasts Damaged by Methylmercuric Chloride

메틸수은으로 손상된 골모세포에 대한 홍화의 효과에 관한 연구

  • 민부기 (원광대학교 의과대학 해부학교실) ;
  • 홍기연 (원광대학교 의과대학 해부학교실) ;
  • 오연균 (원광대학교 의과대학 해부학교실) ;
  • 신용일 (원광대학교 의과대학 해부학교실) ;
  • 한선희 (원광보건대학) ;
  • 이상복 (원광보건대학) ;
  • 신민교 (원광대학교 한의과대학) ;
  • 전병훈 (원광대학교 한의과대학) ;
  • 공호준 (원광대학교 한의과대학) ;
  • 류도곤 (원광대학교 한의과대학) ;
  • 박승택 (원광대학교 의과대학 해부학교실)
  • Published : 2002.08.01
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Abstract

To evaluate the osteotoxic effect of methylmercuric chloride(MMC) on cultured mouse osteoblasts, cytotoxic effect was measured by MTT assay after cultured mouse osteoblasts were incubated with various concentrations of MMC for 20 hours. The protective effect of Flos Carthami(FC) against MMC-induced osteotoxicity was also examined in these cultures. MMC decreased cell viability of cultured mouse osteoblasts remarkably in a dose- and time-dependent manners. In protective effect of FC was remarkably effective in blocking the osteotoxicity induced by MMC. From aboved the results, it is suggested that MMC induce osteotoxicity, and the selective herba extract such as FC is very effective in blocking MMC-mediated neurotoxicity on cultured mouse osteoblasts.

Keywords

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