Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Screening on Monoamine Oxidase B Inhibitor and Antioxidant Activity from the Water Extracts of Medicinal Plants

한약재 물 추출물의 Monoamine Oxidase B의 활성 억제 및 항산화 활성 검색

  • Lee Hyung Chul (Department of Pathology, College of Oriental Medicine, Wonkwang University) ;
  • Hwang Sang-Gu (Department of Pathology, College of Oriental Medicine, Wonkwang University) ;
  • Kim Dae Gun (Department of Pathology, College of Oriental Medicine, Wonkwang University) ;
  • Ju Sung Min (Department of Pathology, College of Oriental Medicine, Wonkwang University) ;
  • Youl Hyung-Keun (Department of Periodontology, College of Dentistry, Wonkwang University) ;
  • Kim Won Shin (Biological Science Major Division of Natural Science and Technology College of Natural Science, Wonkwang University) ;
  • An Won Gun (Department of Biology College of Natural Sciences. Kyungpook University) ;
  • Jeon Byung Hun (Department of Pathology, College of Oriental Medicine, Wonkwang University)
  • 이형철 (원광대학교 한의과대학 병리학교실) ;
  • 황상구 (원광대학교 한의과대학 병리학교실) ;
  • 김대근 (원광대학교 한의과대학 병리학교실) ;
  • 주성민 (원광대학교 한의과대학 병리학교실) ;
  • 유형근 (원광대학교 치과대학 치주과학교실) ;
  • 김원신 (원광대학교 자연과학대학 생명과학기술부) ;
  • 안원근 (경북대학교 자연과학대학) ;
  • 전병훈 (원광대학교 한의과대학 병리학교실)
  • Published : 2002.06.01
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Abstract

This present study was designed to screen medicinal plants for the treatment of brain diseases such as Parkinson's disease or Alzheimer's disease. The inhibitory activity of monoamine oxidase B (MAO-B) was investigated in the water extracts of 56 species traditional medicines. Among the tested medicinal plants, E. lathyris, R. palmatum, F. rhynchonphylla, E. caryophyllata, E. pekinensis and H. syriacus were showed the strong inhibitory activity against MAO-B. Therefore, MAO-B inhibitory activity of 6 traditional medicine extracts in the different concentration (2.5, 6.5 and 12.5 ㎍/ml) was determined. The inhibitory effect of MAO-B was detected with dose dependently in 6 traditional plants extracts. E. caryophyllata and R. palmatum were showed the highest inhibitory activity, the MAO-B inhibitory activity at 2.5㎍ of herbal extract being 58% and 52%, respectively. The water extracts of 6 species were tested on antioxidant activity using radical scavenging effects against ABTS/sup +/. The water extracts of R. palmatum, E. caryphyllata, E. pekinensis and H. syriacus were showed strong antioxidant capacity at 20 ㎍ concentration. Among the 56 medicinal plants investigated, the water extracts of R. palmatum and E. caryphyllata were showed significant antioxidant capacity and MAO-B inhibiory activity. Therefore, R. palmatum and E. caryphyllata are expected to ameliorate the clinical symptoms in Parkinson's disease due to significant MAO-B inhibition and radical scavenging effect.

Keywords

References

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