Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Study on Antitumor and Antimetastatic Effect of Kamigedang-tang

가미저당탕의 항암 및 항전이 효과에 관한 연구

  • Lee Dong Hoon (Oriental Medical College, Daejon University) ;
  • Kim Dong Hee (Oriental Medical College, Daejon University) ;
  • Kang In Cheol (Graduate School of East-West Medical Science, Kyunghee University) ;
  • Park Young Mi (Department of Biology, Inchon University) ;
  • Song Gyu Yong (Graduate School of East-West Medical Science, Kyunghee University) ;
  • Kim Sung Hoon (Graduate School of East-West Medical Science, Kyunghee University)
  • 이동훈 (대전대학교 한의과대학) ;
  • 김동희 (대전대학교 한의과대학) ;
  • 강인철 (경희대학교 동서의학대학원) ;
  • 박영미 (인천대학교 생물학과) ;
  • 송규용 (경희대학교 동서의학대학원) ;
  • 김성훈 (경희대학교 동서의학대학원)
  • Published : 2002.06.01
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Abstract

The purpose of this study was to investigate the effect of Kamigedang-tang(KGDT) water extract on the antitumor and anti metastatic activity. The results were summarized as follows: KGDT extracts exhibited a significant cytotoxicity against P388, SK-MEL-2, SK-OV-3, and B16-F10 cell lines and showed significant inhibitoty effect on DNA topoisomerase I from calf thymus. The T/C% was 122.9% in KGDT treated group in S-180 bearing ICR mice. Also, KGDT extracts exhibited efficient affect adhesive effect of A549 cell to complex extracellular matrix. In CAM assay, KGDT extracts inhibited angiogenesis at 15㎍/egg concentration insignificantly as compared with control. These results suggested that KGDT extracts might be usefully applied for prevention and treatement of cancer.

Keywords

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