Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effect of Benincasae Semen on Cultured Mouse Cerebral Neurons Damaged by Streptozotocin

동과가 Streptozotocin에 의해 손상된 대뇌신경세포에 미치는 영향

  • Lee Whan Bong (School of Medicine, Wonkwang University) ;
  • Lee Kang Chang (Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee Ki Nam (Graduate School of Oriental Medicine, Wonkwang University) ;
  • Hong Gi Youn (School of Medicine, Wonkwang University) ;
  • Suk Seung Whan (School of Medicine, Wonkwang University) ;
  • Cho Chung Cu (School of Medicine, Wonkwang University) ;
  • Jung Sean Kwan (School of Medicine, Wonkwang University) ;
  • Hur Jung Mu (Medical School of Chunbuk National University) ;
  • Lee Sang Bark (WonkWang Health Science College, Wonkwang University) ;
  • Seo Eun A (medicinal resources research center, Wonkwang University) ;
  • Song Ho Jun (College of Oriental Medicine, Wonkwang University) ;
  • Lee Young Chan (College of Oriental Medicine, Wonkwang University) ;
  • Park Seung Taeck (School of Medicine, Wonkwang University)
  • Published : 2002.06.01
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Abstract

It has been suggested that oxidative stress may play an important role in the pathogenesis of diabetic complications. The purpose of this study was to examine the oxidative stress of streptozotocin(STZ) in the cultured mouse cerebral neurons and the preventing effect of vitamin E and and Benincasae Semen(BS) on STZ-induced neurotoxicity. Cytotoxic effect of STZ and neuroprotective effect of antioxidant and BS were performed by MTT assay. 30 μM STZ decreased cell viability in dose-and time-dependent mannner, and vitamin E and BS diminished STZ-induced neurotoxicity in these cultures. From above the results, STZ has toxic effect. and antioxidants, vitamin E or herb extract of BS is very effective against STZ-induced neurotoxicity in cultured cerebral neurons of neonatal mouse.

Keywords

References

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