동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제16권2호
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  • Pages.215-219
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  • 2002
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  • 1738-7698(pISSN)
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  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
권호 표지

한약재 물 추출물의 아세틸콜린에스테라제 활성 억제 검색

Screening of the Acetylcholinesterase Inhibitors from Water Extracts of the Medicinal Plants

  • 이형철 (원광대학교 한의과대학 병리학교실) ;
  • 황상구 (원광대학교 한의과대학 병리학교실) ;
  • 이영찬 (원광대학교 한의과대학 병리학교실) ;
  • 김대근 (원광대학교 한의과대학 병리학교실) ;
  • 박영준 (원광대학교 한의과대학 병리학교실) ;
  • 김태은 (상지대학교 한의과대학 생리학교실) ;
  • 김명동 (상지대학교 한의과대학 생리학교실) ;
  • 전병훈 (원광대학교 한의과대학 병리학교실)
  • Lee Hyung Chul (Department of pathology, College af Oriental Medicine. Wonkwang University) ;
  • Hwang Sang-Gu (Department of pathology, College af Oriental Medicine. Wonkwang University) ;
  • Lee Young Chan (Department of pathology, College af Oriental Medicine. Wonkwang University) ;
  • Kim Dae Gun (Department of pathology, College af Oriental Medicine. Wonkwang University) ;
  • Park Young Jun (Department of pathology, College af Oriental Medicine. Wonkwang University) ;
  • Kim Tae Eun (Department of Physiology, College af Oriental Medicine. Sangji University) ;
  • Kim Moung Dong (Department of Physiology, College af Oriental Medicine. Sangji University) ;
  • Jeon Byung Hun (Department of pathology, College af Oriental Medicine. Wonkwang University)
  • 발행 : 2002.04.01
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초록

Over the past decade there has been a resurgence of interest in botanical products for their medicinal uses. This present study was designed to screen medicinal plants for the treatment of brain diseases such as Alzheimer's disease or aging. We tested the effects of the water extracts from 41 species medicinal plants on acetylcholinesterase (AChE) inhibition and antioxidant activity in vitro. Among them, Euodia rutaecarpa, Rubus coreanus, Achyranthes japonica, Morus alba, Salvia miltiorrhiza, Liriope platyphylla, and Rheum palmatum showed relatively AChE inhibition potency over 80%. Among the 7 medicinal plants investigated, E. rutaecarpa showed an 25%, 65%, and 93% inhibitions on AChE activity at 2.5, 12.5, and 25 ㎍/㎖ of the extract, respectively and was found to be one of most potent AChE inhibitor. The water extracts from 4 species (E. rutaecarpa, R. coreanus, A. iaponica, and M. alba) were tested on their antioxidant capacities using radical scavenging effect against ABTS/sup ㆍ+/. Among the 4 medicinal plants investigated, both R. coreanus and E. rutaecarpa showed significant antioxidant capacity. Therefore, E. rutaecarpa and R. coreanus are expected to ameliorate the clinical symptoms in Alzheimer's disease due to significant AChE inhibition and radical scavenging effect.

키워드

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