Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

The Effects of Crataegus pinnatifida BGE. var. major N.E. BR Extract on the Alzheimer's Disease Model

산사육이 Alzheimer's Disease 병태 모델에 미치는 영향

  • Jung In Chul (Department of Oriental Neuropsychiatry. College of Oriental Medicine, Daejeon University) ;
  • Lee Sang Ryong (Department of Oriental Neuropsychiatry. College of Oriental Medicine, Daejeon University)
  • 정인철 (대전대학교 한의과대학 신경정신과학교실) ;
  • 이상룡 (대전대학교 한의과대학 신경정신과학교실)
  • Published : 2002.04.01
Download PDF
⟨ Previous Next ⟩

Abstract

This research investigates the effect of the Crataegus pinnatifida BGE. var. major N.E. BR(CPVM) on Alzheimer's disease. The CPVM extract suppressed the expression of IL-1 β, IL-6, APP, AChE mRNA in PC-12 cells treated with CT105. The CPVM extract suppressed the AChE activity, and the production of APP significantly in PC-12 cells treated with CT105. The CPVM extract group showed a significant inhibitory effect on the memory deficit for the mice with Alzheimer's disease induced by CT105 in the Morris water maze experiment. The CPVM extract suppressed the over-expression of IL-1 β, TNF- α and ROS in the mice with Alzheimer's disease induced by CT105. This study suggests that CPVM may be effective for the prevention and treatment of Alzheimer's disease.

Keywords

References

  1. 浙江中醫雜志 v.31 no.10 從痰瘀論治노년기치매硏究進展 徐浩;馬笭云
  2. 동의신경정신과학회지 v.7 no.1 치매에 對한 文獻的 考察 鄭仁哲;李相龍
  3. 동의신경정신과학회지 v.8 no.2 Alzheimer型 치매患者 2例에 對한 臨床的 考察 김보경(외)
  4. 安神淸腦湯이 Alzheimer's disease 病態 모델의 生化學的 變化 및 記憶에 미치는 影響 김보경
  5. Trends Cell Biol v.8 no.11 The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease. Selkoe DJ https://doi.org/10.1016/S0962-8924(98)01363-4
  6. Neuroscience v.95 no.1 Suppression of an amyloid beta peptide -mediated calcium channel response by a secreted beta- amyloid precursor protein. Li WY;Butler JP;Hale JE;McClure DB;Little SP;Czilli DL;Simmons LK https://doi.org/10.1016/S0306-4522(99)00479-0
  7. J Biol Chem v.274 no.49 Gangliosides activate cultured rat brain microglia. Pyo H;Joe E;Jung S;Lee SH;Jou I https://doi.org/10.1074/jbc.274.49.34584
  8. Glia v.28 no.2 Neuronal death in cytokine-activated primary human brain cell culture ; role of tumor necrosis factor-alpha. Downen M;Amaral TD;Hua LL;Zhao ML;Lee SC https://doi.org/10.1002/(SICI)1098-1136(199911)28:2<114::AID-GLIA3>3.0.CO;2-O
  9. Neurology v.52 no.4 In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer's disease. Kuhl DE;Koeppe RA;Minoshima S;Snyder SE;Ficaro EP;Foster NL;Frey KA;Kilbourn MR https://doi.org/10.1212/WNL.52.4.691
  10. Arq Neuropsiquiatr v.56 no.3B Treatment of Alzheimer's disease ; critical evaluation of the use of anticholinesterase. Almeida OP https://doi.org/10.1590/S0004-282X1998000400029
  11. 張氏景岳全書 張介賓
  12. 國譯石室秘錄 陳士澤
  13. 辨證奇問全書 錢鏡湖
  14. 備急千金要方 孫思邈
  15. 實用中醫腦病學 陳 輝(외)
  16. 實用中醫內科學 黃大東(외)
  17. 本草學 全國韓醫科大學本草學敎授(共著)
  18. 中藥大辭典 김창민(외 역)
  19. 동의신경정신과학회지 v.7 no.1 치매에 대한 한의학적 임상연구 이승기(외)
  20. 동의신경정신과학회지 v.9 no.1 Dementia of Alzheimer Type에 관한 한의학적 임상연구 김보균(외)
  21. 동의신경정신과학회지 v.10 no.1 Vascular Dementia에 關한 韓醫學的 臨床硏究 현경철;김종우;황의완
  22. 동의신경정신과학회지 v.9 no.1 형방지황탕이 Alzheimer's disease 모델 백서의 학습과 기억에 미치는 영향 조윤숙(외)
  23. 동의신경정신과학회지 v.9 no.2 한약물의 치매 치료에 관한 실험적 연구 박순권(외)
  24. 동의신경정신과학회지 v.10 no.1 香附子八物湯이 Alzheimer's disease 모델 白鼠의 학습과 기억에 미치는 影響 강현근;김종우;황의완
  25. 동의생리병리학회지 v.15 no.2 導痰益氣活血湯이 알츠하이머질환 病態 모델의 生化學的 變化 및 行動에 미치는 影響 鄭仁哲;李相龍
  26. 山査 抽出液이 白鼠의 肥滿模型에 미치는 影響 高光宰
  27. 위점막 보호효과에 대한 山査의 항산화작용과 SH기의 영향 辛東勳
  28. 統計學槪論 金宇哲(외)
  29. Neurosci Lett v.234 no.1 A novel pathogenic mutation(Leu262Phe) found in the presenilin 1 gene in early-onset Alzheimer's disease. Forsell C;Froelich S;Axelman K;Vestling M;Cowburn RF;Lilius L;Johnston JA;Engvall B;Johansson K;Dahlkild A;Ingelson M;St. George-Hyslop PH;Lannfelt L https://doi.org/10.1016/S0304-3940(97)00603-4
  30. Brain Res v.785 no.2 Amyloid-beta peptide activates cultured astrocytes ; morphological alterations, cytokine induction and nitric oxide release. Hu J;Akama KT;Krafft GA;Chromy BA;Van Eldik LJ https://doi.org/10.1016/S0006-8993(97)01318-8
  31. Neuroreport v.11 no.15 Toxic effect of the beta-amyloid precursor protein C-terminus fragment and $Na^+/Ca^+$ gradients. Bryan-Sisneros AA;Fraser SP;Suh YH;Djamgoz MB https://doi.org/10.1097/00001756-200010200-00019
  32. FASEB J v.14 no.11 Carboxyl-terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity. Kim HS;Park CH;Cha SH;Lee JH;Lee S;Kim Y;Rah JC;Jeong SJ;Suh YH https://doi.org/10.1096/fj.14.11.1508
  33. Free Radic Biol Med v.31 no.9 Amyloid-beta ; an antioxidant that becomes a pro-oxidant and critically contributes to Alzheimer's disease. Kontush A https://doi.org/10.1016/S0891-5849(01)00688-8
  34. J Neurochem v.78 no.2 Homocysteine potentiates beta-amyloid neurotoxicity ; role of oxidative stress. Ho PI;Collins SC;Dhitavat S;Ortiz D;Ashline D;Rogers E;Shea TB https://doi.org/10.1046/j.1471-4159.2001.00384.x
  35. Biochem J v.338 Amyloid precursor protein metabolism in fibroblasts from individuals with one, two or three copies of the amyloid precursor protein (APP) gene. Racchi M;Johnston JA;Flood FM;Cowburn RF;Govoni S https://doi.org/10.1042/0264-6021:3380777
  36. Mol Neurobiol v.1 no.4 Gene transfer into the nervous system. Breakefield XO;Geller AI https://doi.org/10.1007/BF02935741
  37. J Neurochem v.57 no.3 Tumor necrosis factor-induced proliferation of astrocytes from mature brain is associated with down-regulation of glial fibrillary acidic protein mRNA. Selmaj K;Shafit-Zagardo B;Aquino DA;Farooq M;Raine CS;Norton WT;Brosnan CF https://doi.org/10.1111/j.1471-4159.1991.tb08225.x
  38. Neuroreport v.12 no.7 Reactive oxygen species mediate A beta(25-35)-induced activation of BV-2 microglia. Kang J;Park EJ;Jou I;Kim JH;Joe EH https://doi.org/10.1097/00001756-200105250-00030
  39. J FASEB v.14 Carboxyl-terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity. Kim HS;Park CH;Cha SH;Lee JH;Lee SW;Kim YM;Rah JC;Jeong SJ;Suh YH https://doi.org/10.1096/fj.14.11.1508
  40. Life Sciences v.61 no.23 Effect of a carboxy-terminal fragment of Alzheimer's amyloid precursor protein on expression of proinflammatory cytokines in rat glial cells. Chong YH https://doi.org/10.1016/S0024-3205(97)00936-3
  41. J Phamacol Exp Ther v.272 no.1 FR121196, a potential antidementia drug, ameliorates the impaired memory of rat in the Morris water maze. Yamazaki M;Matsuoka N;Kuratani K;Ohkubo Y;Yamaguchi I