Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Immuno-modulatory and Anti-carcinogenic Property of Cordyceps militaris and Paecilomyces japonicus

동충하초의 면역조절 및 항암효과

  • Jung Han Sol (College of Oriental medicine, Woosuk University) ;
  • Kwon Jin (Department of Health Administration. Kunjang College) ;
  • Lee Tae Gyu (Division of Food Nutrition and Engineering, Woosuk University) ;
  • Lee Kwang Gyu (College of Oriental medicine, Woosuk University) ;
  • Oh Chan Ho (Division of Biotechnology, Woosuk University)
  • 정한솔 (우석대학교 한의과대학) ;
  • 권진 (군장대학 보건행정과) ;
  • 이태규 (우석대학교 식품영양식품공학부) ;
  • 이광규 (우석대학교 한의과대학) ;
  • 오찬호 (우석대학교 생명공학부)
  • Published : 2002.04.01
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Abstract

The purpose of this research was to investigate the immuno-modulatory effect and anti-carcinogenic property of Cordyceps militaris(CM) and/or Paecilomyces japonicus (PJ). The proliferation of cultured splenocytes and thymocytes were enhanced by the addition of 10 ㎍/ml of CM and/or PJ. B lymphocytes subpopulation in splenocytes were increased both CM and/or PJ administered(p.o. for 7 days)-mice. Thymic T lymphocytes, especially TH cells were significantly increased in CM-administered mice. CM and/or PJ treatment inhibited the cell viability of L 1210 mouse leukemia and HL60 human leukemia cells and induced the apoptosis of L1210 and HL60 cells. In addition, CM and/or PJ increased the hemaggutination(HA) titer against SRBC. These results suggest that CM and/or PJ have an immuno-modulatory action and anti-carcinogenic property.

Keywords

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