Study on Antitumor and Immunomodulatory Effects of Cambodian Phellinus linteus

캄보디안 상황버섯의 항암 및 면역조절작용에 대한 연구

  • Lee Hyo Jeong (Graduate School of East-West Medical Science, Kyunghee University) ;
  • Park Jung Min (Graduate School of East-West Medical Science, Kyunghee University) ;
  • Song Gyu Yong (Graduate School of East-West Medical Science, Kyunghee University) ;
  • Kang Kyung Sun (Department of Veterinary Public Health, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University) ;
  • Kim Sung Hoon (Graduate School of East-West Medical Science, Kyunghee University)
  • 이효정 (경희대학교 동서의학대학원) ;
  • 박정민 (경희대학교 동서의학대학원) ;
  • 송규용 (경희대학교 동서의학대학원) ;
  • 강경선 (서울대학교 수의과대학) ;
  • 김성훈 (경희대학교 동서의학대학원)
  • Published : 2002.04.01

Abstract

Phellinus Iinteus from Cambodia was confirmed to have a homologous DNA sequencec to Phellinus Iinteus. Antitumor and immunomodulatory activities were evaluated with aquous extract of Cambodian Phellinus Iinteus(CPL). CPL didn't show any significant cytotoxicity on HT1080, Sarcoma 180 and B16BL6, whereas it inhibited the relaxation of DNA topoisomerase I from the concentration of 250ug/ml. In the pulmonary colonization assay it inhibited pulmonary metastasis by B16BL6 in C57BL6 mice to 36%, 36.9% and 55.5% at various doses of 2 mg, 20 mg and 50 mg. From FACS analysis with splenocytes pretreated with CPL, it significantly increased lymphoblast and induced production of IL-2. These results indicate Cambodian Phellinus Iinteus has antitumor and immunomodulatory activities still suggesting more study on its mechanism and effective compound in detail.

Keywords

References

  1. 한국약용버섯도감 박완희;이호득
  2. 동의보감 허준
  3. 본초강목 李時珍
  4. Immunopharmacology v.41 The inhibitory effect of polysaccharides isolated from Phelinus linteus on tumor growth and metastasis. Han Sang-Bae;Lee Chang-Woo;Jeon Yong-Jin https://doi.org/10.1016/S0162-3109(98)00063-0
  5. Int J Immunopharmacol. v.18 no.5 Stimulation of humoral and cell mediated immunity by polysaccharide from mushroom Phellinus linteus. Kim HM;Han SB;Oh GT;Kim YH;Hong DH;Hong ND;Yoo ID https://doi.org/10.1016/0192-0561(96)00028-8
  6. Chem Pharm Bull v.44 no.5 Characterization of carbohydrate-peptide linkage of acidic heteroglycopeptide with immuno-stimulating activity from mycelium of Phellinus linteus. Lee JH;Cho SM;Song KS;Hong ND;Yoo ID https://doi.org/10.1248/cpb.44.1093
  7. Chem Pharm Bull v.32 no.12 B-lymphocyte-stimulating polysaccharide from mushroom Phellinus linteus. Song KS;Cho SM;Lee JH;Kim HM;Han SB;Ko KS;Yoo ID
  8. Gan To kagaku Ryoho v.28 no.8 Antiangiogenic and antimetastatic effects of toremifene citrate. Okada M;Ogasawara A;Sekine K;Seno C;Nishikawa K
  9. J Exp Clin Cancer Res v.16 no.2 Effect of viscum album in the inhibition of lung metastasis in mice induced by B16F10 melanoma cells. Antony S;KuttanR;Kuttan G.
  10. Cancer Letter v.124 no.2 Dietary flaxseed supplementation and experimental metastasis of melanoma cells in mice. Yan L;Yee JA;LiD;McGuire MH;Thmpson LU https://doi.org/10.1016/S0304-3835(97)00470-9
  11. Biotechnology Letters v.23 Production of a hypoglycemic, extracellular polysaccharide from the submerged culture of the muchroom, Phellius linteus. Dong-Hyun Kim;Byung-Keun Yang;Sang-Chul Jeong;Jun-Bo Park;Sung-Pill Cho;Surajit Das;Jong-Won Yun;Chi-Hyun Song https://doi.org/10.1023/A:1010312513878