Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of Hwangryunhaedok-tang plus Yukmijihwang-tang add Chogudeung on Blood Pressure and Renal Function in Spontaneously Hypertensive Rats

황연해독탕 합 육미지황탕 가 조구등이 자발적 고혈압 백서의 혈압 및 현장 기능에 미치는 영향

  • Sohn Eun Jin (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kang Dae Gill (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee An Sook (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kim Bok Hae (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee Ho Sub (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 손은진 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 강대길 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 이안숙 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 김복해 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 이호섭 (원광대학교 한의학전문대학원 한약자원개발학과)
  • Published : 2002.04.01
Download PDF
⟨ Previous Next ⟩

Abstract

The present study examined the effects of water extract of Hwangruynhaedoktang plus Yukmijihwangtang add Chogudeung (HYC) on the blood pressure and renal function in spontaneously hypertensive rats (SHR). The HYC water extract blocked increase of systolic blood pressure (SBP) in SHR. The urinary volume (UV), sodium (UNaV), potassium (UkV), and chloride (UclV) excretions were significantly increased in SHR administered with high dose of water extract of HYC, but urinary osmolality was not changed. The creatinine clearance (Ccr), which is index of glomerular filtration rate (GFR), was increased by administration of HYC, while solute-free water reabsorption (TcH2O) was not changed. Taken together, these results suggest that the depressor effects of HYC, at least in part, caused by diuretic effect due to increase of glomerular filtration rate.

Keywords

References

  1. 주후비급방 葛仙翁
  2. 대한본초학회지 v.14 no.2 조구등(釣鉤藤)의 4-VO로 유발한 흰쥐뇌허혈에 대한 신경방어효과. 이인환;임강현;이종석;숙경호;안덕균;박호균;김호철
  3. 外臺秘要 王燾
  4. 劉河間傷寒三六書 劉完素
  5. 기효양방 方賢
  6. 慶熙韓醫大 論文集 v.5 杜鎬京;朴憲在
  7. 대한한의학회지 v.20 no.1 黃連解毒湯과 溫淸飮이 高血壓 및 高脂血證에 미치는 影響. 金恩善;朴致相;朴昌國
  8. 濟韓東醫學術院 論文集 v.1 no.1 六味地黃湯 및 鹿茸加味方이 흰쥐 糖尿에 對한 免役組織化學的 硏究 변성희
  9. 대한동의병리학회지 v.14 no.2 六味地黃湯加味方이 局所 血流量 및 血壓에 미치는 實驗的 效果. 정현우;백영찬;김정상
  10. 생약학회지 v.30 no.3 六味地黃湯이 카드뮴 중독된 흰쥐의 혈압에 미치는 영향. 임종필;서은실;김훈;송영철
  11. 대한동의병리학회지 v.1 no.2 陽虛證 誘發에 의한 補中益氣湯 및 六味地黃湯의 효과. 이태호
  12. 대한침구학회지 v.13 no.2 六味地黃湯 藥針刺戟이 Cyclosprin A로 誘發된 흰쥐의 腎毒性에 미치는 영향. 조외제;김경호;윤종화
  13. 생약학회지 v.29 no.3 조구등(釣鉤藤)성분의 항경련 효과 Ⅲ. Urisolic acid와 hyperin이 in vitro 뇌 신경전달 관련 물질에 미치는 효과. 김동영;최종원;박종철;이정규
  14. 응용약물학회지 v.5 고지혈증 랫트를 이용한 시호, 작약, 조구등의 항고지혈 효과. 노환성;고우경;박건구;조영환;박영섭
  15. American Journal of Chinese Medicine v.28 no.2 Vasodilatior effect of extract prepared from Uncariae Ramulus on Isolated rat arota. Goto, H.;Sakakibara, I.;Shimada, Y.;Kasahara, Y.;Terasawa. K. https://doi.org/10.1142/S0192415X00000246
  16. Life Sciences v.54 no.26 Gou-teng(from ucaria rhynchophylla miquel)-induced endothelium-dependent relaxations in the isolates rat aorta. Tomaya Kuramochi;Jie Chu;Toshio Suga https://doi.org/10.1016/0024-3205(94)00715-2
  17. American Journal of Chinese Medicine v.27 no.3-4 Effect of Uncariae Ramulus et Uncus on endothelium in spontaneously Hypertensive Rats. Goto, H.;Dhimada, Y.;Tanigawa, K.;Sekiya, N.;Shintani, N.;Terasawa, K. https://doi.org/10.1142/S0192415X99000380
  18. 東醫心系內科學 (上) v.1 李京燮(등)
  19. Harrison's 內科學 (II) v.1 Harrison
  20. 辨證論治 方藥合編 黃道淵
  21. 最新韓方臨床學 裵元植
  22. 腎과 腎病의 證治 李兆華
  23. 전정판 신장학 서울대학교 의과대학
  24. 大韓韓醫學會誌 v.22 no.2 韓藥材들의 안지오텐신轉換酵素 抑制劑 作用의 檢索. 강대길;오현철;손은진;권태오;이호섭
  25. Analytical Science & Technology v.16 no.4 조구등 중의 알칼로이드 분석. 박만기;박정일;김종문;한상범;한방희;강종성
  26. Planta Med. v.57 no.5 Ca$^{2+}$channel blocking effects of hirsuine, an indole alkaloid from Uncaria genus, in the isolated rat aorta. Yano, S.;Horiuch, H.;Horie, S.;Aimi, N.;Sakai, S.;Watanabe, K. https://doi.org/10.1055/s-2006-960134
  27. Planta Med. v.5 Hypertensive action of 3 alpha-dihydrocadambine, an indole alkaloid glycoside of Uncaria hooks. Aisaka, K.;Hattori, Y.;Kihara, T.;Ishihara, T.;Endo, K.;Hikino, H.
  28. Yakugaku Zasshi v.93 no.4 Studies of plants containing indole alkaloids 2. on the alkaolids of Uncaria rhynchophylla Miq. Haginiwa, J.;Sakai, S.;Aimi, N.;Yamanaka, E.;Shinma, N. https://doi.org/10.1248/yakushi1947.93.4_448