Effects of BanhabackchulChunma-tang on the Vascular Relaxation and its mechanism

혈관 긴장성 조절에 미치는 반하백출천마탕

  • Kim Yon Tae (Department of Physiology, Dongguk University College of Oriental Medicine) ;
  • Chae Jong Koo (Department of Physiology, Dongguk University College of Oriental Medicine) ;
  • Kim Gil Whon (Department of Physiology, Dongguk University College of Oriental Medicine) ;
  • Shin Heung Mook (Department of Physiology, Dongguk University College of Oriental Medicine)
  • 김윤태 (동국대학교 한의과대학 생리학교실) ;
  • 채종구 (동국대학교 한의과대학 생리학교실) ;
  • 김길훤 (동국대학교 한의과대학 생리학교실) ;
  • 신흥묵 (동국대학교 한의과대학 생리학교실)
  • Published : 2002.02.01

Abstract

Hypertension is not only a well-established cardiovascular risk factor but also increase the risk of atherosclerosis. Most studies conducted to investigate the effectiveness of treatment for cardiovascular disease such as hypertension have focused primarily on conventional drug and physiotherapeutic treatments. BanhabackchulChunma-tang(半夏白朮天麻湯:BCT) is popular herbal medicine used in clinic for the treatment of various symptoms of drulatory disorders and weakness of digestive system, including anorexa and nausea with vertigo, severe headache, vomiting and so on. However, the mechanisms underlying its efficacy are unknown. This study investigated the effects of BCT as an alternative medication on the contraction induced by phenylephrine and KCI in rat thoratic aorta. BCT revealed siginificant relaxation on phenylephrine-induced arterial contraction, but revealed noncompetitive effect on concentration responses of phenylephrine-induced contraction. Treatment of N-L/sup ω/ -argine methyl ester(L-NAME) and methylene blue(MB)(10/sup -5/M) reduced the relaxation of BCT. BCT also increased in vitro NO production. It suggest that the relaxation effect of BBT is related with NO pathway, becausse the effect of L-NAME and MB are due to inhibition of NO synthesis from endothelial cells. These results indicate that BCT would be effective in hypertension treatment and its mechanism of relaxtion on arterial contraction is likely to be related with NO production, blocking of α-receptor and signal transduction after receptor activation.

Keywords

References

  1. 醫方集解 왕인암
  2. 경희한의대논문집 v.7 半夏白朮湯이 鎭痛, 鎭靜, 鎭痙 효과에 미치는 영향 金洛雄;宋一炳
  3. Life Sci. v.51 Pharmacological evalation of GS-389, anovel THI analog related to higenamine, on vascular smooth muscle Chang, K.C.;Lim, J.K.; Park, C.W. https://doi.org/10.1016/0024-3205(92)90220-J
  4. Proc. Natl. Acad. Sci. USA v.84 Macrophage synthesis of nitrite, nitrate and N-nitrosamines: Precursors and role of the respiratory burst. Iyengar, R.;Stuehr, D.J.;Marletta, M.A. https://doi.org/10.1073/pnas.84.18.6369
  5. Cancer Res. v.47 Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of chemosensitivity testing. Carmichael, J.;DeGraff, W.G.;Gazdar, A.F.;Minna, J.D.;Mitchell, J.B.
  6. 疑難病中醫治療及硏究 鮑學全;仝小林 (主編)
  7. 高血壓 趙光勝
  8. 現代中醫內科學 何紹奇
  9. 東醫心系內科學 具本泓
  10. The Cell:a molecular approach Cooper, G.M.
  11. Ann Rev Pharmacol Toxicol. v.25 The pharmacological and physiological role of cycilic GMP in vascular smooth muscle relaxation. Ignarro, L.J.;kadowitz, P. https://doi.org/10.1146/annurev.pa.25.040185.001131
  12. M. Barany(ed) Biochemistry of smooth muscle Contraction The Nitric Oxide-Cyclic GMP Signaling System. Lincoln,T.M.;Cornwell,T.L.;Komalavilas,P.;McMillanCrow, L.A.;Boerth, N.J.
  13. J. Cardiovasc. Pharmacol v.20 no.3 Release of multiple endothelium-derived relaxing factors from porcine coronary areries Myer,P.R.;Guerra,R.J.;Harrison,D.G. https://doi.org/10.1097/00005344-199209000-00008
  14. Circ. Res. v.65 no.1 Biological actions and propeties of endothelium- derived nitric oxide formed and released from artery and vein Ignarro,L.J. https://doi.org/10.1161/01.RES.65.1.1