Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Study on Anitmetastatic Effects of Antivascular-first

항혈관 1호의 항전이에 관한 연구

  • Son Chang Kyu (Department of Internal Medicine, college of Oriental Medicine, Daejeon University) ;
  • Cho Chong Kwan (Department of Internal Medicine, college of Oriental Medicine, Daejeon University) ;
  • Lee Seung ho (Department of Internal Medicine, college of Oriental Medicine, Daejeon University)
  • 손창규 (대전대학교 한의과대학 내과학교실) ;
  • 조종관 (대전대학교 한의과대학 내과학교실) ;
  • 이승호 (대전대학교 한의과대학 내과학교실)
  • Published : 2002.02.01
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Abstract

To evaluate the anti metastatic effect of Antivascular-first(AntiV-F), we investigated cytotoxic effect on B16-F10 and HMCB. gene expression of MMP-9 and nm23-H1, and survival. After treating with AntiV-F, AntlV-F promoted cytotoxic effect on B16-F10 and HMCB as its density, compared with Control. AntiV-F inhibited gene expression of MMP-9 in the L+14 and HMCB cell line compared with Control. On the other hand AntiV-F increases gene expression of nm23-H1 and survival about 30% compared with Control. These results suggest that AntiV-F has effects on anti-metastasis can be used for treatment of cancer patients and preventing recurrence.

Keywords

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